DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and ADGRF4

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001334784.1	Gene:	ADGRF4 / 221393	HGNCID:	19011	Length:	695	Species:	Homo sapiens

Alignment Length:	288	Identity:	64/288 - (22%)
Similarity:	113/288 - (39%)	Gaps:	82/288 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 CILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGGDLNLWNNICSLAGYTNYFFALASHFW 280
            ||:.|||.|....:..::|..|    ..|...|            |:|....:.::||.|:..||
Human   442 CIVNIAVSLLTANVWFIIGSHF----NIKAQDY------------NMCVAVTFFSHFFYLSLFFW 490

  Fly   281 LSVMSHQIWKNLRLI-------NRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNW 338
            :      ::|.|.:|       .|..:|...:|....|:|.|.|:...|..:     ..|:|
Human   491 M------LFKALLIIYGILVIFRRMMKSRMMVIGFAIGYGCPLIIAVTTVAI-----TEPEK--- 541

  Fly   339 IPGVGLYR---CWINTYDWSAMIYLYGPMLILSLFN-VVTFILTVNHIMKIKSSVKSSTQQQRKC 399
                |..|   ||:|..:..|::....|..::...| :|..::.||   ..:.|:.||..|
Human   542 ----GYMRPEACWLNWDNTKALLAFAIPAFVIVAVNLIVVLVVAVN---TQRPSIGSSKSQ---- 595

  Fly   400 IQNNDFLLYLRLS-------VMMGVT---GISEVI-----TYFVKRHKFWRQVLRVPNFFHLGSG 449
                |.::.:|:|       .::|:|   ||:.:|     |:.:        :..:.|.|. |..
Human   596 ----DVVIIMRISKNVAILTPLLGLTWGFGIATLIEGTSLTFHI--------IFALLNAFQ-GFF 647

  Fly   450 IVVF--VLFILKRSTFQMIMERISGPRR 475
            |::|  ::....|...:|.|..:.|..|
Human   648 ILLFGTIMDHKIRDALRMRMSSLKGKSR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	45/192 (23%)
ADGRF4	NP_001334784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..695		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810