DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and lat-1

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001366731.1	Gene:	lat-1 / 174419	WormBaseID:	WBGene00002251	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	300	Identity:	64/300 - (21%)
Similarity:	105/300 - (35%)	Gaps:	120/300 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 ISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWA--GGD-LNLWNNIC--------- 263
            ::.||||::|                 || :...|..|||::  ||| :.:..|:|
Worm   554 LTYVGCIISI-----------------IC-LLLTFFAYLIFSRNGGDRVFIHENLCLSLAIAEIT 600

  Fly   264 SLAGYTN---------------YFFALASHFWLSVMSHQIWKNL-RLINRDERSYHFLIYNIYGW 312
            .|||.|.               |.| |::..|:.:..:.|.:.| .:...|.|.:.:|   :.|:
Worm   601 FLAGITRTEDSLQCGIIAVALMYMF-LSALTWMLLEGYHIHRMLTEVFPSDPRRFTYL---LVGY 661

  Fly   313 GTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWI---NTYDWSAMIYLYGPMLILSLFNVVT 374
            ..|||:|.:.||.:......||           .||:   |.:.|    :..||...:...|.:.
Worm   662 IPPAIITLVAYLYNSDGFGTPD-----------HCWLSTQNNFIW----FFAGPACFIFCANSLV 711

  Fly   375 FILT------------------VNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRLSVMMGVTGIS 421
            .:.|                  |:....|::.||.|                |.|:.::|||.|.
Worm   712 LVKTLCTVYQHTSGGYLPCRHDVDSGRSIRNWVKGS----------------LALASLLGVTWIF 760

  Fly   422 EVITYFVKRHKFWRQVLRVPNFFHLGSGIVVFVLFILKRS 461
            .:         ||.:..|         .||:..:|.:..|
Worm   761 GL---------FWVEDSR---------SIVMAYVFTISNS 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	51/235 (22%)
lat-1	NP_001366731.1	Gal_Lectin	51..133	CDD:396628
		HormR	180..244	CDD:214468
		GAIN	258..462	CDD:406802
		GPS	493..541	CDD:197639
		7tmB2_latrophilin-like_invertebrate	548..808	CDD:320556	63/299 (21%)
		TM helix 1	551..575	CDD:320556	9/38 (24%)
		TM helix 2	584..605	CDD:320556	4/20 (20%)
		TM helix 3	615..637	CDD:320556	4/22 (18%)
		TM helix 4	655..671	CDD:320556	6/18 (33%)
		TM helix 5	690..713	CDD:320556	5/26 (19%)
		TM helix 6	744..766	CDD:320556	11/46 (24%)
		TM helix 7	771..796	CDD:320556	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910