DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and lat-2

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001040724.1	Gene:	lat-2 / 173771	WormBaseID:	WBGene00002252	Length:	1338	Species:	Caenorhabditis elegans

Alignment Length:	274	Identity:	58/274 - (21%)
Similarity:	119/274 - (43%)	Gaps:	44/274 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 IPKSMPAVPQVG-TISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGGDLNLWNN 261
            :..::..|..:| .||:|...|::.|:.:.:.|:|:..........|..:..|::..|.....|.
Worm   893 LASALDVVSTIGCAISIVCLALSVCVFTFFRNLQNVRNSIHRNLCLCLLIAELVFVIGMDRTGNR 957

  Fly   262 I-CSLAGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAITYLV 325
            . |.:.....::|.|:|..|:.:..:|::..|..:....|:..||.| ::.:||||::.||:..:
Worm   958 TGCGVVAILLHYFFLSSFCWMLLEGYQLYMMLIQVFEPNRTRIFLYY-LFCYGTPAVVVAISAGI 1021

  Fly   326 DWAWEDRPDKLNWIPGVGLYRCWINTYD---WSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKS 387
              .|||.        |...| |||:|..   |:    ...|::::...|::..::.:..::.::|
Worm  1022 --KWEDY--------GTDSY-CWIDTSTPTIWA----FVAPIIVIIAANIIFLLIALKVVLSVQS 1071

  Fly   388 SVKSSTQQQRKCIQNNDFLLYLR--------LSVMMGVTGISEVITYFVKRHKFWRQVLRVPNFF 444
            ..::...:....::.:..||.|.        |:.:.|.||     |.|.     |     :....
Worm  1072 RDRTKWGRIIGWLKGSATLLCLLGITWIFGFLTAVKGGTG-----TAFA-----W-----IFTIL 1121

  Fly   445 HLGSGIVVFVLFIL 458
            :...||.:|||.::
Worm  1122 NCTQGIFIFVLHVV 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	41/190 (22%)
lat-2	NP_001040724.1	CLECT	52..193	CDD:214480
		Gal_Lectin	242..322	CDD:280328
		CLECT	330..>399	CDD:295302
		HormR	479..542	CDD:214468
		GAIN	556..>660	CDD:293098
		GPS	837..884	CDD:197639
		7tm_4	894..1129	CDD:304433	55/265 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840