DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and Adgrl2

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_599235.3	Gene:	Adgrl2 / 171447	RGDID:	620835	Length:	1487	Species:	Rattus norvegicus

Alignment Length:	194	Identity:	42/194 - (21%)
Similarity:	85/194 - (43%)	Gaps:	27/194 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 VGTISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGGDLNLWNNICSL-AGYTNY 271
            |..:.:..||.|...:..::..||.:.|.....:|  ..:::...|.|...:...|.: ||..::
  Rat   861 VSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLF--IAEFIFLIGIDKTQYTIACPVFAGLLHF 923

  Fly   272 FFALASHFWLSVMSHQIWKNLRLINRDERSY-HFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDK 335
            || ||:..|:.:...|::  |.|:...|..| ....|.:.|:..||.:..::..:|:
  Rat   924 FF-LAAFSWMCLEGVQLY--LMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDY-------- 977

  Fly   336 LNWIPGVG-LYRCWI---NTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQ 395
                ...| |..||:   |.:.||    ..||:..:.|.|::..::|:..::|..:::|..:.:
  Rat   978 ----KSYGTLEACWLHVDNYFIWS----FIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSR 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	41/191 (21%)
Adgrl2	NP_599235.3	Gal_Lectin	49..129	CDD:396628
		OLF	142..398	CDD:413369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..462
		HormR	469..533	CDD:214468
		GAIN	542..764	CDD:406802
		GPS	788..840	CDD:197639
		7tm_GPCRs	848..1129	CDD:421689	42/194 (22%)
		TM helix 1	850..875	CDD:410628	4/13 (31%)
		TM helix 2	884..906	CDD:410628	4/23 (17%)
		TM helix 3	915..942	CDD:410628	8/29 (28%)
		TM helix 4	954..974	CDD:410628	4/19 (21%)
		TM helix 5	991..1020	CDD:410628	8/32 (25%)
		TM helix 6	1036..1087	CDD:410628
		TM helix 7	1091..1116	CDD:410628
		Latrophilin	1128..1487	CDD:396778
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1160
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1386..1428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810