Protein Alignment mthl6 and LOC1280992

DIOPT Version :10

• Sequence 1: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: XP_320866.3
• Gene: LOC1280992 / 1280992
• VectorBaseID: AGAMI1_010236
• Length: 682
• Species: Anopheles gambiae
• Alignment Length: 479
• Identity: 92/479 - (19%)
• Similarity: 169/479 - (35%)
• Gaps: 163/479 - (34%)

  Fly    86 IRFCCPRNKMMPNSRCSDGLTENLKRI-------NPYLKITLEDGTIGKYYLLTDMI-----VLR 138
            :|.|||..:.:        ::|:.|.:       :.||...:    :.::|  .|.|     .||
Mosquito   210 MRKCCPPGESL--------VSEHSKHVSCQKDAPSSYLPQPI----VAQFY--RDCIEDLEEELR 260

  Fly   139 YEFRY---CEK---VVSV---QEDQYKLYENGSFMI-----KPDVNWTLSKQWYCLHPRLED--- 186
            .:.||   |..   :||.   ..|...:.:|||.::     ..||..|     |||.....|
Mosquito   261 LDVRYGNPCPSEGGMVSFGAHTNDTLYVIQNGSLLVIYGGKDYDVYDT-----YCLDYDRTDGAL 320

  Fly   187 -----PNSIWILEHVYIPKSMPAVPQVGTISMVGCIL-TIAVYLYIKKLRNLLGKCFI--CYVF- 242
                 |:.:.::  |.:.|....:..:..|..:..:| |..:|:.:.||.:|.|:...  |..|
Mosquito   321 LAYVCPSEVRVM--VDVVKGQLFLLTICLIVAIPALLVTALLYIIVPKLHDLHGRALAMNCVNFA 383

  Fly   243 ------CKFVQYLIWAGGDLNLWNNICSLAGYTNYFFALASHFWLSV----MSHQIWKNL---RL 294
                  | |.||.  ..|...|.:::. |..|..||. ||:.|||.|    .....|..:   :.
Mosquito   384 IALLLEC-FFQYR--NRGKRMLMDDMV-LENYAEYFI-LATFFWLLVNCGNNCFHAWYYVPRGKK 443

  Fly   295 INRDERSYHFLIYNIYG-----W----------GTPAIMTAITYLVDWAWEDRPDKLNWIPGVGL 344
            .|..|.:..|.:|..:.     |          |||||..
Mosquito   444 ANTLEDNQRFALYAAFAQLIPLWIILSYSMTPAGTPAIKH------------------------- 483

  Fly   345 YRCWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDF---- 405
                          ||:.|:.:......:..::|:..:.::|:...:..|.:::.:|:..:
Mosquito   484 --------------YLFIPIGVTLGLGSLCLLVTLLGLTRLKNCYYTCHQIRQRLVQSGQYEELC 534

  Fly   406 ------------LLYLR-----LSVMMGVTGISEVITYFVKRHKFWRQVLRVPNFFHL---GSGI 450
                        ::|:.     |.|:||.......:||:.        ...:|.|:.:   ..||
Mosquito   535 KYVPVCGRKVNKVIYMNKYTVPLFVVMGTIWTVMAVTYYA--------TYDLPIFYDILFGFQGI 591

  Fly   451 VVFVLFILKRSTFQMIMERISGPR 474
            ::||:|:.....::.|.:.::..|
Mosquito   592 LMFVIFVCMPRPYETIRQWLNERR 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Methuselah_N	25..195	CDD:429053	30/142 (21%)
		7tmB3_Methuselah-like	211..471	CDD:410632	59/315 (19%)
		TM helix 2	234..256	CDD:410632	8/30 (27%)
		TM helix 3	264..291	CDD:410632	11/30 (37%)
		TM helix 4	304..324	CDD:410632	8/34 (24%)
		TM helix 5	353..382	CDD:410632	4/28 (14%)
		TM helix 6	400..427	CDD:410632	7/47 (15%)
		TM helix 7	435..460	CDD:410632	7/27 (26%)
LOC1280992	XP_320866.3	None