DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl6 and adgrf8

DIOPT Version :9

Sequence 1:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster
Sequence 2:XP_021324214.1 Gene:adgrf8 / 100537224 ZFINID:ZDB-GENE-130531-41 Length:1719 Species:Danio rerio


Alignment Length:313 Identity:62/313 - (19%)
Similarity:115/313 - (36%) Gaps:82/313 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 VPQVGTIS-MVGC---------------ILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIW-- 251
            |.|||..| ::.|               ||...:..||..:...:.  .|..|.|..::.::|  
Zfish  1356 VKQVGNDSGIITCECNHTTSFSILMSPFILDSLILAYITYIGVTIS--MISLVLCLIIEAIVWRS 1418

  Fly   252 ---AGG---------DLNLWN--------NICSLAG-------------------YTNYFFALAS 277
               |.|         .::|.|        |:|.:.|                   :..:||.||.
Zfish  1419 VTSARGVTVVSSYMRHISLVNIALSLLIANVCFIIGAAISDLEKPTPVGRCSPVVFFIHFFYLAV 1483

  Fly   278 HFWLSVMSH-QIWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPG 341
            .||:.:... .::..:.:..:..|.....|....|:|.|.::.:||.    |....|...     
Zfish  1484 FFWMLISGMLLLYMTVMVFGQMSRIKMIAISFPVGYGAPLLIASITV----ASTAGPQNY----- 1539

  Fly   342 VGLYRCWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDFL 406
            |....||:|..:..|::....|.|.:...|:|..::.:..:  :.:.|.::||...|    |.|.
Zfish  1540 VSKQACWLNWNESRALLAFVIPALTIVAINLVVLVVVLYKM--LGTGVGAATQPSEK----NTFF 1598

  Fly   407 LYLR----LSVMMGVT---GISEVITYFVKRHKFWRQVLRVPNFFHLGSGIVV 452
            :.:|    |:.:.|:|   ||..:::..:..|..:..:.....||.|..|.::
Zfish  1599 VVVRCVAFLTPLFGLTWGFGIGTMLSSALGVHVLFTLLNAFQGFFILLFGTIL 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl6NP_788473.1 Mth_Ecto 25..197 CDD:119403
7tm_4 211..398 CDD:304433 44/244 (18%)
adgrf8XP_021324214.1 EGF_CA 156..189 CDD:214542
EGF_CA 324..357 CDD:214542
EGF_CA 508..>540 CDD:214542
EGF_CA 673..706 CDD:214542
Ig 899..968 CDD:325142
GPS 1337..1379 CDD:307782 6/22 (27%)
7tm_GPCRs 1387..1660 CDD:333717 54/282 (19%)
TM helix 1 1390..1414 CDD:320095 5/25 (20%)
TM helix 2 1434..1455 CDD:320095 4/20 (20%)
TM helix 3 1470..1492 CDD:320095 6/21 (29%)
TM helix 4 1513..1529 CDD:320095 4/15 (27%)
TM helix 5 1551..1574 CDD:320095 5/22 (23%)
TM helix 6 1598..1623 CDD:320095 6/24 (25%)
TM helix 7 1627..1652 CDD:320095 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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