DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk26 and asic1a

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_021333995.1	Gene:	asic1a / 791696	ZFINID:	ZDB-GENE-040513-2	Length:	614	Species:	Danio rerio

Alignment Length:	556	Identity:	116/556 - (20%)
Similarity:	203/556 - (36%)	Gaps:	156/556 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 TTIHGIRYLGEKKRPLLERLFWI----SVLVLSVFTCVKLTLNIWDK---WNNNPVIVSFAEKST 135
            :|:|||.::...::...:...|:    |.|...::.|:       |:   :...|.:....|.:|
Zfish   143 STLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCI-------DRIQFYLEYPHVTKLDEITT 200

  Fly   136 PVWQIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVSQVCEPHLH 200
            ||  :.|||||:|.....|.......|.||               :.:...|..:..:|.|.||.
Zfish   201 PV--MVFPAVTICNLNSIRFSRITRNDLYH---------------AGELLALLNSRHEVREAHLV 248

  Fly   201 DVTLGNKTRRGMEIIDALTEVSP----HFD-------------DTYLNCKWRNSPVKCSDIFHKF 248
            :.::       ||::.:.|:...    ||:             |..|:|::|.||.:..| |...
Zfish   249 EESV-------MEVLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCRPED-FSVV 305

  Fly   249 VTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLGPGAR 313
            .|..|.|::||                                     |.:|.| |...:..|..
Zfish   306 FTRYGKCYTFN-------------------------------------SGETGP-PRVSVKGGMG 332

  Fly   314 AGLYLFMGGAEIDFDDMCRGPV----------QGFKILLHTPGDVAQVSKQYFRIPFDQEVLISI 368
            .||.:.:   :|..|:..  ||          .|.|:.:|:..:...:.:..|.:....:..:|.
Zfish   333 NGLEIML---DIQQDEYL--PVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSC 392

  Fly   369 RPKIITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVN 433
            :.:.:.       |.|..............||..||.|.|..:|...:.:..|.|      |.|:
Zfish   393 QEQRLV-------YLPAPWGSCKSTPPSSDYFRAYSISACRTDCETRYLVENCNC------RMVH 444

  Fly   434 MPVCGDASL-------KCYNQAEDELLLREFTQGLVNAGENTRGETE---CNCLPSCTSIAYEAE 488
            ||  |||..       :|.:.|.|.|:                 ||:   |:|...|....|..|
Zfish   445 MP--GDAPYCTPVLYKECAHPALDFLV-----------------ETDSDYCSCETPCNITRYSKE 490

  Fly   489 ISQADFDYKTVINTDSPE-GKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTTDFLANCGGL 552
            :|......|..:...:.: .|.|:...:.:.:  :.:||:...:.|..:.:.|.....|.:.||.
Zfish   491 LSFVKIPSKASVKYLAKKYSKSEKYITENVMV--LDVFFEALNYETIEQRKAYEVAGLLGDIGGQ 553

  Fly   553 LGLFMGVSMLSIVELIYFCTVRLISNLRMRRKTRKE 588
            :|||:|.|:|:|:||  |..:..:...|:.|.:.|:
Zfish   554 MGLFIGASILTILEL--FDYLYEVMKYRLCRCSNKK 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	112/536 (21%)
asic1a	XP_021333995.1	ASC	136..582	CDD:322155	114/549 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.070