Protein Alignment ppk26 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 116/647 - (17%)
• Similarity: 207/647 - (31%)
• Gaps: 178/647 - (27%)

  Fly     8 PHTPSHEVAVRPPPCAANQWKRAALMARMAPAFRETVSDDSEDEVDTKKQIKYGSGFQAAKAIIH 72
            |..|....|..|||...:|.....|.|    :|||                           ::.
Human   192 PPRPGPPSAPPPPPKEGHQEGLVELPA----SFRE---------------------------LLT 225

  Fly    73 EYCDYTTIHG-IRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTP 136
            .:|...|||| ||.:..:...|....:.:..|...|..|.:|.|.....| :.||:::.:..|.
Human   226 FFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHW-HRPVLMAVSVHSE- 288

  Fly   137 VWQIPFPAVTVC------PETKTRREIFNFTDSYHQVRDFQSNVSGI--VDLSDKQKGLYGAVSQ 193
              :...|.||:|      |....|.  ....|.:     .:.|:..:  |:||..:..|...|.:
Human   289 --RKLLPLVTLCDGNPRRPSPVLRH--LELLDEF-----ARENIDSLYNVNLSKGRAALSATVPR 344

  Fly   194 VCEPHLH---DVTL------GNKTRRGMEIIDA-------------LTEVSP----HFDD--TYL 230
             .||..|   ::.|      |::.|.|..:.::             :..|..    |:.|  ..|
Human   345 -HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALL 408

  Fly   231 NCKWRNSPVKCSDIFHKFVTEDGV-C-----FSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWN 289
            ...|.:|.......|....:.||: |     .:|:..:....:..:|:               |.
Human   409 PAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGV---------------WT 458

  Fly   290 VEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGP----VQGFKILLHTPGDVAQ 350
            .:                 .||...|:     |..:..:.....|    :.|.::::|.......
Human   459 AQ-----------------RPGITHGV-----GLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPF 501

  Fly   351 VSKQYFRIPFDQEVLISIRPKII-----------TTSDGLKHYEPNRRQCYFQKERELRYFNIYS 404
            :....|.:....|..||||...:           ...:|:              |.||.:...|:
Human   502 LGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGV--------------EVELLHNTSYT 552

  Fly   405 QSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDASL----KCYNQAEDELLLREFTQGLVNAG 465
            :..|.:.|.....:..|.|..:..|.......|..|..    .|:.:...:|
Human   553 RQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDL------------- 604

  Fly   466 ENTRGETECNCLPSCTSIAYEAEISQADFDYKT----VINTDSPEGKEEQSKRQGMKMSRVSIFF 526
            |..|......|...|...|::.....:.:....    .:.|...:|...||.||...:::::|.:
Human   605 ETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVY 669

  Fly   527 KEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELIYF-----CTVRLISNLRMRR 583
            :|..:.:...:.:|.....|:..|.|..|:.|.|:||::||:..     ....::...|:||
Human   670 QELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRR 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	101/561 (18%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		6/18 (33%)
		ENaC	219..784	CDD:273304	107/616 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820