Protein Alignment ppk26 and SCNN1B

DIOPT Version :9

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 128/653 - (19%)
• Similarity: 228/653 - (34%)
• Gaps: 198/653 - (30%)

  Fly    57 QIKYGSGFQAAKAIIHEYCDYTTIHGIRYL---GEKKRPLLERLFWISVLVLSVFTCVK--LTLN 116
            :::.|.|: ..|.::..|||.|..||.:.:   |.||:    .::::..|:.:...|.:  :.:.
Human    32 RLQKGPGY-TYKELLVWYCDNTNTHGPKRIICEGPKKK----AMWFLLTLLFAALVCWQWGIFIR 91

  Fly   117 IWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLS 181
            .:..|.   |.||.   |.....:.|||||:|..:.     |.::...|.::|....:..:::
Human    92 TYLSWE---VSVSL---SVGFKTMDFPAVTICNASP-----FKYSKIKHLLKDLDELMEAVLE-- 143

  Fly   182 DKQKGLYGAVSQVCEPHLHDVTLGNKTRR---------GMEIIDALTEVSPH-------FDDTY- 229
                       ::..|.|   :..|.||.         .:.:||   |.:||       |.|.:
Human   144 -----------RILAPEL---SHANATRNLNFSIWNHTPLVLID---ERNPHHPMVLDLFGDNHN 191

  Fly   230 -------------------------LN---CKWRNSP-----------VKCSDIFHKFVTEDGVC 255
                                     ||   |.:||..           ::.::||.:...::.|.
Human   192 GLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVE 256

  Fly   256 FSFNSLSPAE------IFRAE-----GIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLG 309
            .|:    |.|      :|.||     .....|.....|....:|.:.:....||:
Human   257 MSY----PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSAN---------- 307

  Fly   310 PGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQE----VLISIRP 370
            ||...||.|.:...:.|:.... ....|.:::||.       .:.|   ||.::    .:.....
Human   308 PGTEFGLKLILDIGQEDYVPFL-ASTAGVRLMLHE-------QRSY---PFIRDEGIYAMSGTET 361

  Fly   371 KIITTSDGLKH----YEPNRRQCYFQKERELRYFNIYSQSN-------CELECLANFTLTKCGCV 424
            .|....|.|:.    |.|    |..... |:...|.||..|       |...|..:..:..|.|.
Human   362 SIGVLVDKLQRMGEPYSP----CTVNGS-EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCG 421

  Fly   425 KFSMPRNVNMPVCGDASL----KCYNQAEDELLLREFTQGLVNAGENTRGETECNCLPSCTSIAY 485
            .:..|.......|.:...    .||:..:..:..||...|:              |..||....|
Human   422 HYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGM--------------CKESCNDTQY 472

  Fly   486 EAEISQADFDYKT-------VINTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTT 543
            :..||.||:..:.       |::.:..:.......|:|  :.:::|:|:|..:.|...|......
Human   473 KMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKG--IVKLNIYFQEFNYRTIEESAANNIV 535

  Fly   544 DFLANCGGLLGLFMGVSMLSIVE-------LIYFCTVRLIS---NLRMRR---------KTRKEL 589
            ..|:|.||..|.:||.|:|.::|       .::...::|::   :||.||         .|..||
Human   536 WLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL 600

  Fly   590 LKA 592
            ::|
Human   601 VEA 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	116/600 (19%)
SCNN1B	XP_016879014.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820