Protein Alignment ppk26 and ASIC4

DIOPT Version :10

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_054198812.1
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 666
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 139/640 - (21%)
• Similarity: 232/640 - (36%)
• Gaps: 162/640 - (25%)

  Fly     5 STQPHTPSHEVAV----------RP-PPCAANQWKRAALMAR--------MAPAFR-----ETVS 45
            |..|.:..|.|.|          :| ||....  :...|:||        .:|:.|     |.|.
Human    72 SDSPTSGPHPVPVLFPLALSLEEQPLPPLPLG--RAPGLLAREGQGREALASPSSRGQMPIEIVC 134

  Fly    46 DDSEDEVDTKKQIKYGSGFQ---------AAKAIIHEYCDYTTIHGIRYLGEKKRP---LLERLF 98
            .....|.|.|.:.|.....|         ||...:..:...:|:||   ||....|   .|.|..
Human   135 KIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG---LGRACGPGPHGLRRTL 196

  Fly    99 WISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDS 163
            |...|:.|:...:.....:...:...|.:|:. :.:.|.....|||||:|...:.|....:..|.
Human   197 WALALLTSLAAFLYQAAGLARGYLTRPHLVAM-DPAAPAPVAGFPAVTLCNINRFRHSALSDADI 260

  Fly   164 YHQVRDFQSNVSGIVDLSDKQK-GLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDD 227
            :|     .:|::|   |..|.: |...|..:..||.:.|:.    .|.|.::.|.|.
Human   261 FH-----LANLTG---LPPKDRDGHRAAGLRYPEPDMVDIL----NRTGHQLADMLK-------- 305

  Fly   228 TYLNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVED 292
               :|.:.......|: |....|..|.|::||
Human   306 ---SCNFSGHHCSASN-FSVVYTRYGKCYTFN--------------------------------- 333

  Fly   293 GYSASAD-TSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQ-----GFKILLHTPGDVAQV 351
                 || .|..|:|..|.|  :||.:.:...:.::..:.|...:     |.::.:|:..:...:
Human   334 -----ADPRSSLPSRAGGMG--SGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYI 391

  Fly   352 SKQYFRIPFDQEVLISIRPKIITTSDGLKHYEP----NRRQCYFQKERELRYFNIYSQSNCELEC 412
            .:..|.:....:..:|.:.:.:|       |.|    |.|.....:|.||:.::.||.|.|.|.|
Human   392 HQLGFGVSPGFQTFVSCQEQRLT-------YLPQPWGNCRAESELREPELQGYSAYSVSACRLRC 449

  Fly   413 LANFTLTKCGCVKFSMPRNVNMPVC-GDASLKCYNQAEDELLLREFTQGLVNAGENTRGETECNC 476
            .....|.:|.|....||.|..  :| .:..::|.:...|.|            |....|  .|.|
Human   450 EKEAVLQRCHCRMVHMPGNET--ICPPNIYIECADHTLDSL------------GGGPEG--PCFC 498

  Fly   477 LPSCTSIAYEAEISQADFDYKTVINTDSPE------GKEEQSKRQGMKMSRVSIFFKEAQFLTSR 535
            ...|....|..|||..     .:.|..|..      .:.|...|:...:  :.:||   :.|||.
Human   499 PTPCNLTRYGKEISMV-----RIPNRGSARYLARKYNRNETYIRENFLV--LDVFF---EALTSE 553

  Fly   536 RSE---LYGTTDFLANCGGLLGLFMGVSMLSIVELIYFCTVRLISNLRMRRKTRK 587
            ..|   .||.:..|.:.||.:|||:|.|:|:::|::.:  :..:|..|::|..|:
Human   554 AMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDY--IYEVSWDRLKRVWRR 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:459966	113/519 (22%)
ASIC4	XP_054198812.1	ENaC	167..615	CDD:273304	117/543 (22%)