Protein Alignment ppk26 and ASIC5

DIOPT Version :10

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 121/529 - (22%)
• Similarity: 202/529 - (38%)
• Gaps: 123/529 - (23%)

  Fly    68 KAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWD---------KW-N 122
            |...|::...|:.|||..: .:.|..:.|:.|:.|::.||      :|..|.         .| .
Human    35 KKFDHDFAISTSFHGIHNI-VQNRSKIRRVLWLVVVLGSV------SLVTWQIYIRLLNYFTWPT 92

  Fly   123 NNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNV---SGIVDLSDKQ 184
            ...:.|.:.||      :.|||||.|                 .:..||::.   .|::..
Human    93 TTSIEVQYVEK------MEFPAVTFC-----------------NLNRFQTDAVAKFGVIFF---- 130

  Fly   185 KGLYGAVSQVCEPHLHDVTLGNKT-----------RRGMEIIDALTEVSPHFDD-TYLNCKWRNS 237
              |:..||:|.  ||.::| .|.|           .:...|::.:.....:.:: |.|:|::...
Human   131 --LWHIVSKVL--HLQEIT-ANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGK 190

  Fly   238 PVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSP 302
            |....|..|.| ||.|.||:||.....:..|...:       ....||:.:||..  .|..|
Human   191 PCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSV-------SGRGLSLLFNVNQ--EAFTD--- 242

  Fly   303 YPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQEVLIS 367
              |..||                 |.|      .|...::|:|..|.|........|......::
Human   243 --NPALG-----------------FVD------AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVT 282

  Fly   368 IRPKIITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNV 432
            || ::.|.     |.|....:|  ....:|:.|:.||.|.|..||.|.....:||||.|.:| ..
Human   283 IR-QVKTV-----HQEYPWGEC--NPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLP-GY 338

  Fly   433 NMPVCGDASLKCYNQAEDELLLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQADFDYK 497
            .:.........|.:...|.:..::..         |.|....:|..||..|.|.|.||.:.|..:
Human   339 GIECDLQKYFSCVSPVLDHIEFKDLC---------TVGTHNSSCPVSCEEIEYPATISYSSFPSQ 394

  Fly   498 TVINTDSPEGKEEQSKRQ-GMKMSRVSIFFKEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSM 561
            ..:...|.  |..||::. ...:.::.|.:.:..:..:::.:....::.||:.||.||||.|.|:
Human   395 KALKYLSK--KLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASL 457

  Fly   562 LSIVELIYF 570
            ::|:|:|.:
Human   458 ITIIEIIEY 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:459966	119/521 (23%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	119/521 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)