Protein Alignment ppk26 and asic1b

DIOPT Version :10

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_999956.1
• Gene: asic1b / 407672
• ZFINID: ZDB-GENE-040513-1
• Length: 557
• Species: Danio rerio
• Alignment Length: 550
• Identity: 108/550 - (19%)
• Similarity: 203/550 - (36%)
• Gaps: 142/550 - (25%)

  Fly    79 TIHGIRYL-GEKKRPLLERLFW--ISVLVLSVFTCVKLTLNIWDK---WNNNPVIVSFAEKSTPV 137
            ::||..:: .|.|:..:.:..|  :.:|.:|:|     .|.:.|:   :.....:....|::..
Zfish    74 SLHGANHVFVEDKKFSIRQGLWALVFLLAISMF-----LLQVVDRVIYYLQYDYVTLLDERNAK- 132

  Fly   138 WQIPFPAVTVCPETKTRREIFNFTDSYHQ--VRDFQSNVSGIVDLS---DKQKGLYGAVSQVCEP 197
             .:.|||:|:|.....||...:::|....  :..::.|::..:.|:   |:|    |:...:.|
Zfish   133 -NMTFPAITLCNYNTFRRSQLSYSDLLFMGPLLGYEDNMAPGIPLAPEPDRQ----GSRFSLAE- 191

  Fly   198 HLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRNSPVKC-SDIFHKFVTEDGVCFSFNSL 261
                  ..|:||..|             ||..|.|.:...  :| ::.:.:..|..|.|::|||
Zfish   192 ------FFNRTRHRM-------------DDMLLECNFAGK--ECGAEHWREIFTRYGKCYTFNS- 234

  Fly   262 SPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEID 326
                                        .:||......|.        .|...||.:.:   :|.
Zfish   235 ----------------------------GQDGRPLLITTK--------GGMGNGLEIML---DIQ 260

  Fly   327 FDDMCRGPV----------QGFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKIITTSDGLKH 381
            .|:..  ||          .|.|:.:||..:...:.:..|.:....:..:|.:.:.:|      :
Zfish   261 QDEYL--PVWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQEQRLT------Y 317

  Fly   382 YEPNRRQCYFQKEREL--RYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDASLK- 443
            ..|....|   |...:  .:||.||.:.|.::|...:.:..|.|....||.:.  |.|.....|
Zfish   318 LPPPWGDC---KATPIDSDFFNTYSITACRIDCETRYLVENCNCRMVHMPGDA--PYCTPEQYKE 377

  Fly   444 CYNQAEDELLLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGK 508
            |.:.|.|.|:.|:              ...|.|...|....|..|:|        .:...|....
Zfish   378 CADPALDFLVERD--------------NDYCVCETPCNMTRYGKELS--------FVRIPSKASA 420

  Fly   509 EEQSKRQGMKMSRVS-------IFFKEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVE 566
            :..:|:.......:|       |||:...:.|..:.:.|.....|.:.||.:|||:|.|:|:|:|
Zfish   421 KYLAKKYNKTEQYISDNIMVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILE 485

  Fly   567 LIYFCTVRLISNLRMRRKTRKELLKAVNKD 596
            |  |..:..:...::.|..:|:..::.|.:
Zfish   486 L--FDYLYEVIKFKLCRCAKKKHQRSNNNE 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:459966	104/522 (20%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..57
		ENaC	66..548	CDD:273304	108/549 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	477..479		1/1 (100%)