Protein Alignment ppk26 and asic4a

DIOPT Version :10

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_999952.1
• Gene: asic4a / 407668
• ZFINID: ZDB-GENE-040513-5
• Length: 539
• Species: Danio rerio
• Alignment Length: 573
• Identity: 126/573 - (21%)
• Similarity: 211/573 - (36%)
• Gaps: 140/573 - (24%)

  Fly    51 EVDTKKQIKYGSGFQAAKAIIHEYCDYTT-----------IHGIRYLGEKKRPLLERLFW----I 100
            |.|.|::   |:.....:::|.|.|...|           :|||.::....|..:.:..|    :
Zfish    13 EEDEKQK---GNQDGDKESLIEESCSPPTKDLAGFASASSLHGINHIFVSGRLGVRQTLWALAFL 74

  Fly   101 SVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYH 165
            ..|.|.::...|..::    :..:|.:.:..|::||  ::.|||||:|...:.|.......|.||
Zfish    75 VSLALFLYQAAKCAIS----YLEHPHVTALNEEATP--EMVFPAVTICNINRFRFSALTDADIYH 133

  Fly   166 QVRDFQSNVSGIVDLSDKQK-GLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTY 229
                 .:|::|   |..|.| |......:...|.:.|:.  |:|...:|             :..
Zfish   134 -----LANLTG---LPPKNKDGHKPTDLEYPAPDMQDIF--NRTGHQLE-------------EML 175

  Fly   230 LNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEG-------IIPDF-------IFRE 280
            .:|.:........| |....|..|.|::||..........:|       |:.|.       |::|
Zfish   176 KSCNFSGQNCSAED-FTVVYTRYGKCYTFNGNKTTSRKTKQGGMGNGLEIMLDIQQDDYLPIWKE 239

  Fly   281 ENRLSMDWNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTP 345
            .|..|::..:..... |.|..||.:: ||.|...|...|:.         |
Zfish   240 TNETSLEAGIRVQIH-SQDEPPYIHQ-LGFGVSPGFQTFVS---------C-------------- 279

  Fly   346 GDVAQVSKQYFRIPFDQEVLISIRPKIITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCEL 410
                            ||..::..|            :| ...|....|:.:..::.||.|.|.|
Zfish   280 ----------------QEQRLTYLP------------QP-WGNCRSTSEQMIPGYDTYSISACRL 315

  Fly   411 ECLANFTLTKCGCVKFSMPRNVNMPVCGDASLKCYNQAEDELLLREFTQGLVNAGENTRGETECN 475
            .|.....|.:|.|....||.:.|  :|..:.:||.::|...|             :.:.|:| |.
Zfish   316 RCETLEVLRECKCRMVHMPGDAN--ICTPSDIKCVDKALALL-------------QKSSGDT-CF 364

  Fly   476 CLPSCTSIAYEAEISQADFDYKTVINTDSPE-GKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSEL 539
            |...|....|..|:|......|......|.: .|.|...|....:  :.|||:...:.|..:.:.
Zfish   365 CETPCNLTRYGKELSMVKIPSKGSARYLSRKYDKSEDYIRDNFLV--LDIFFEALNYETIEQKKA 427

  Fly   540 YGTTDFLANCGGLLGLFMGVSMLSIVELI-YFCTV---RLISNLRMRRKTRKE 588
            |.....|.:.||.:|||:|.|:|:|:|:: |...|   ||...||.:|..:|:
Zfish   428 YDVAGLLGDIGGQMGLFIGASVLTILEILDYVYEVIKHRLERLLRPQRDDKKQ 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:459966	112/527 (21%)
asic4a	NP_999952.1	ENaC	44..472	CDD:273304	114/529 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	446..448		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..494		2/7 (29%)