DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and asic4b

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_999951.1	Gene:	asic4b / 407667	ZFINID:	ZDB-GENE-040513-6	Length:	558	Species:	Danio rerio

Alignment Length:	587	Identity:	120/587 - (20%)
Similarity:	213/587 - (36%)	Gaps:	166/587 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QIKYGSGFQA----------------------AKAIIHEYCDYTTIHGI-RYLGEKKRPLLERLF 98
            :||:..|.:|                      ..|.:..:...:::||: |.||..:|....:..
Zfish     8 KIKFAEGEEAKGASTEGGGTGMLDEGLRRQKEGMADLASFASSSSLHGLARALGTSERLGFRQTL 72

  Fly    99 WISVLVLSVFTCVKLTLNIWD-KWN-----NNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREI 157
            |...|::|      |.|.::. .|:     ..|.:.:..|::..  ::.|||:|:|...:.|...
Zfish    73 WGLALLVS------LGLFLYQATWSAATYLERPHLAALREETRR--ELTFPAITLCNVNRFRFSA 129

  Fly   158 FNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVS 222
            ....|.||     .:|::|:...|  :||...:..|...|::.|:.    .|.|.::.|.|.  |
Zfish   130 LTDADIYH-----LANLTGLPPKS--RKGHRPSELQYPPPNMLDIF----QRTGHQLEDMLK--S 181

  Fly   223 PHFDDTYLNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMD 287
            .:|...  ||.        |:.|....|..|.|::||.                     |:.|
Zfish   182 CNFSGQ--NCS--------SEDFSVVYTRYGKCYTFNG---------------------NKTS-- 213

  Fly   288 WNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPV----------QGFKILL 342
                            |.||...|...||.:.:   :|..|:..  |:          .|.::.:
Zfish   214 ----------------PKRVRQGGTGNGLEMML---DIQQDEYL--PIWRETNETTLEAGIRVQI 257

  Fly   343 HTPGDVAQVSKQYFRIPFDQEVLISIRPKIITTSDGLKHYEPNR-RQCYFQKERELRYFNIYSQS 406
            |:..:...:.:..|.:....:..:|.:.:.:|       |.|.. ..|....|..:..::.||.|
Zfish   258 HSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLT-------YLPQPWGNCRASSEPVIPGYDTYSVS 315

  Fly   407 NCELECLANFTLTKCGCVKFSMPRNVNMP----VCGDASLKCYNQAEDELLLREFTQGLVNAGEN 467
            .|.|.|.:.....:|.|      |.|:||    :|..:.:||.::|...|             :.
Zfish   316 ACRLHCESTQVQRECNC------RMVHMPGDADICAPSKIKCVDKALASL-------------QK 361

  Fly   468 TRGETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR--------VSI 524
            :.|:: |.|...|....|..|:|......:         |......|:..|...        :.|
Zfish   362 STGDS-CPCETPCNLTRYGKELSMVKIPSR---------GSARYLSRKYQKSEEYIRDNFLILDI 416

  Fly   525 FFKEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVEL---IYFCTVRLISNLRMRRKTR 586
            ||:...:.|..:.:.|.....|.:.||.:|||:|.|:|:|:|:   ||......|..|...:|::
Zfish   417 FFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKPKKSQ 481

  Fly   587 KE 588
            |:
Zfish   482 KQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	110/528 (21%)
asic4b	NP_999951.1	ASC	54..497	CDD:295594	115/541 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26504
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.970