DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and rpk

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	264/579 - (45%)
Similarity:	374/579 - (64%)	Gaps:	58/579 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TVSD---DSEDEVDTKKQIKYGSGFQAAKAII---HEYCDYTTIHGIRYLGEKKRPLLERLFWIS 101
            |:||   ||...:|...:.:..:|..|.:..|   ||||..|:|||::||||::||..||:||:.
  Fly     2 TISDSELDSSKGIDLTFRRRRKAGSVACEGFITTYHEYCRNTSIHGVQYLGEQERPFRERIFWLF 66

  Fly   102 VLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETK----------TRRE 156
            |.::|::.|..|..:.:.||...||||||||||||||.|||||||||.|||          |..:
  Fly    67 VFLISIYGCSTLIQSAYTKWTETPVIVSFAEKSTPVWNIPFPAVTVCSETKRVLKQKGKETTYAD 131

  Fly   157 IFN-FTDSYHQVRDFQ-SNVSGIVDLSDKQKGLYGAVSQVCEPHLHDVTL--GNKTRRGMEIIDA 217
            ::: |::.....|.|: .|||.: ::.:.:..|:...:|:.|   .|:.|  |:    .::..|.
  Fly   132 LYSQFSEDMRASRVFRPENVSAL-EMEEFRTLLHVCNTQIIE---EDIPLIAGD----DLDYFDV 188

  Fly   218 LTEVSPHFDDTYLNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREEN 282
            |..:.|.||..:..|:|.:...:|...|.|.:||:|:|::||.|...||:|      |..::.::
  Fly   189 LQRMLPQFDRYFFYCRWLSRFGECETFFRKTLTEEGICYTFNGLRATEIYR------DDTYQYQH 247

  Fly   283 R---LSMD--------WNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQ 336
            .   |.|:        |.:|.||:..:|...:|.|||..|||:|::|.:...:.:.|..||||||
  Fly   248 SGEPLEMENISSQHTAWTLETGYALDSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQ 312

  Fly   337 GFK------ILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKIITTSDGLKHYEPNRRQCYFQKER 395
            |||      :|||.|.||.|||||:.|||..:||||:::|.:||.|.|:..|.|.||||:...||
  Fly   313 GFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHER 377

  Fly   396 ELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDASLKCYNQAEDELLLREFTQ- 459
            .||:|.:|::|||:|||||||||||||||||||||||:|||||:..:.||::||.|||:|||.:
  Fly   378 SLRFFKVYTESNCQLECLANFTLTKCGCVKFSMPRNVDMPVCGEDKIHCYDRAERELLVREFKRV 442

  Fly   460 GLVNAG-ENTRG-ETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKR-QGMKMSR 521
            ..:||| ||:|. |:.|||:|:|||:.|..|||||:||.:.::   ..||..|..|. .|.:|||
  Fly   443 KALNAGRENSRSVESACNCMPACTSLVYNTEISQANFDLEEML---VAEGDTEFLKEYPGSQMSR 504

  Fly   522 VSIFFKEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELIYFCTVRLISNLR 580
            :||:||::||:||:||||||.|:|||||||:.|||||.|:||:||:||..|:||.:||:
  Fly   505 LSIYFKQSQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNLK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	247/530 (47%)
rpk	NP_001246909.1	ASC	39..552	CDD:279230	246/529 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449999
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900