Protein Alignment ppk26 and ASIC2

DIOPT Version :9

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 136/579 - (23%)
• Similarity: 215/579 - (37%)
• Gaps: 186/579 - (32%)

  Fly    80 IHGIRYL--------GEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVI--VSFAEKS 134
            :||:|::        |..:|    |..|    ||:..|...|.|:    |::|.::  :|| ...
Human    66 LHGLRHMCAGRTAAGGSFQR----RALW----VLAFCTSFGLLLS----WSSNRLLYWLSF-PSH 117

  Fly   135 TPV---W--QIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVSQV 194
            |.|   |  |:||||||||.....|....:..|.|     :..:..|::           ..::.
Human   118 TRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLY-----YAGHWLGLL-----------LPNRT 166

  Fly   195 CEPHLHDVTLGNKTRRG--MEIIDALTEVSP-HF---------------DDTYLNCKWRN---SP 238
            ..|.:.::..|::.||.  .::.|....:.| ||               :|..|:||:|.   .|
Human   167 ARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGP 231

  Fly   239 VKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPY 303
            ...|.:|.|:    |.|:.|||                             .|||       .|.
Human   232 HNFSSVFTKY----GKCYMFNS-----------------------------GEDG-------KPL 256

  Fly   304 PNRVLGPGARAGLYLFMGGAEIDFDDMCRGPV----------QGFKILLHTPGDVAQVSKQYFRI 358
            ...|.| |...||.:.:   :|..|:..  |:          .|.|:.:|:..:.
Human   257 LTTVKG-GTGNGLEIML---DIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEP---------- 305

  Fly   359 PFDQEVLISIRPK----IITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLT 419
            ||.||:...:.|.    :.|....|.:..|...:|. ..|..|.:|.:||.:.|.::|...:.:.
Human   306 PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVE 369

  Fly   420 KCGCVKFSMPRNVNMPVCGDASLKCYNQ----AEDEL-LLREFTQGLVNAGENTRGETECNCLPS 479
            .|.|      |.|:||  |||......|    ||..| ||.|            :....|.|...
Human   370 NCNC------RMVHMP--GDAPFCTPEQHKECAEPALGLLAE------------KDSNYCLCRTP 414

  Fly   480 CTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR----VSIFFKEAQFLTSRRSELY 540
            |....|..|:|......||     |.:..|::..:....:|.    :.|||:...:.|..:.:.|
Human   415 CNLTRYNKELSMVKIPSKT-----SAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAY 474

  Fly   541 GTTDFLANCGGLLGLFMGVSMLSIVEL---IYFCTVRLISNLRMRRKTRKELLKAVNKD 596
            .....|.:.||.:|||:|.|:|:|:||   ||    .||         :::||..:.|:
Human   475 EVAALLGDIGGQMGLFIGASILTILELFDYIY----ELI---------KEKLLDLLGKE 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	130/551 (24%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	136/579 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.970