DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and ppk7

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_609016.2	Gene:	ppk7 / 33886	FlyBaseID:	FBgn0031802	Length:	573	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	127/635 - (20%)
Similarity:	231/635 - (36%)	Gaps:	190/635 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPCAANQWKRAALMARMAPAFRETVSDDSEDEVDTKKQIKYGSGFQAAKAIIHEYCDYTTIHGIR 84
            ||....|.::.:..:|:|....:                   |.:|.|.    .:...|||||:.
  Fly     7 PPSKLQQQQQPSRSSRLAQQLAQ-------------------SSWQLAL----RFGKRTTIHGLD 48

  Fly    85 YLGEKKRPLLERLFW----ISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKST--PVWQIPFP 143
            .|...|....||..|    :|..:.:|:.|:.|:...      |.........||  ||::||||
  Fly    49 RLLSAKASRWERFVWLCTFVSAFLGAVYVCLILSARY------NAAHFQTVVDSTRFPVYRIPFP 107

  Fly   144 AVTVC----------PETKTR----------REIF-----NFTDSY-------HQVRDFQSNVSG 176
            .:|:|          .|.|:|          :|:|     .:.|:|       .::|:..:.:..
  Fly   108 VITICNRNRLNWQRLAEAKSRFLANGSNSAQQELFELIVGTYDDAYFGHFQSFERLRNQPTELLN 172

  Fly   177 IVDLSDKQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRNSPVKC 241
            .|:.|                               :::|.:|.   ..::....|.||:....|
  Fly   173 YVNFS-------------------------------QVVDFMTW---RCNELLAECLWRHHAYDC 203

  Fly   242 SDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNR 306
            .:||.|..:::|:|::||||...|..|.:.:.|.:.:|.              .::...|....|
  Fly   204 CEIFSKRRSKNGLCWAFNSLETEEGRRMQLLDPMWPWRT--------------GSAGPMSALSVR 254

  Fly   307 VL------GPGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQEVL 365
            ||      .||.|.                 ...::|..:::..|  ....:..:| :..:.|..
  Fly   255 VLIQPAKHWPGHRE-----------------TNAMKGIDVMVTEP--FVWHNNPFF-VAANTETT 299

  Fly   366 ISIRPKIITTSDGLKHYEPNRRQCYFQKERELRYFN-----IYSQSNCELECLANFTLTKCGCV- 424
            :.|.|.|....:..:....::|||.|..|...:.|.     :|...||:.||...:.:..|.|.
  Fly   300 MEIEPVIYFYDNDTRGVRSDQRQCVFDDEHNSKDFKSLQGYVYMIENCQSECHQEYLVRYCNCTM 364

  Fly   425 -------KFSMPRNVNMPVC----GDASLKCYNQAEDELLLREFTQGLVNAGENTRGETECNCLP 478
                   ::...|..:: :|    .|..:..:|..|.|.:..:| ||:           .|.|..
  Fly   365 DLLFPPGQYRSCRAQDL-LCLAEHNDLLIYSHNPGEKEFVRNQF-QGM-----------SCKCFR 416

  Fly   479 SCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTT 543
            :|.|:.|.:::..|........|....:               :.:.|:....:..|.|.::|..
  Fly   417 NCYSLNYISDVRPAFLPPDVYANNSYVD---------------LDVHFRFETIMVYRTSLVFGWV 466

  Fly   544 DFLANCGGLLGLFMGVSMLSIVELIYFCTVRL----ISNLRMRRKTRKEL 589
            |.:.:.||:.|||:|.|::|.:||.||..:.:    :..||.|.|.|:::
  Fly   467 DLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPAFGLDGLRRRWKARRQM 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	112/556 (20%)
ppk7	NP_609016.2	ASC	38..493	CDD:279230	112/556 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920