DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and ppk28

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	155/586 - (26%)
Similarity:	271/586 - (46%)	Gaps:	108/586 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RETVSDDSEDEVDTKKQIKYGSGFQAAKAIIHEYCDYTTIHGIRYLGEKKRPLLERLF----WIS 101
            :::.|||.|:.:.::..||        ::::: |...:|:||::|:.|:...:.||:|    ::.
  Fly    19 KDSESDDDENTICSRAAIK--------RSVVY-YLKNSTLHGLKYIAEESITIPERIFFGLAFVL 74

  Fly   102 VLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYHQ 166
            |::||||    ...|::.||:.:|:|:|.:.|......:||||:|:|   ...:.:.:..|   :
  Fly    75 VVILSVF----FISNVYVKWSASPIIISTSAKQKLTSNMPFPAITIC---NLNQALLSKVD---R 129

  Fly   167 VRDFQSNVSGIVDLSDKQ--------------KGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDA 217
            :....:|.|.::.|.|:.              |.:...|:|.||..|
  Fly   130 IGRTSTNFSLLMGLCDQGGDTTISYIGTWKYFKAILVDVAQPCEKML------------------ 176

  Fly   218 LTEVSPHFDDTYLNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREEN 282
                        |.|.:.:....||.:|...:|:||:|.:||:|.|:.:.|.        :.::.
  Fly   177 ------------LYCSFGSREEDCSWLFTSILTDDGLCCNFNALHPSYLIRN--------YSDDV 221

  Fly   283 RLS----------MDWNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQ- 336
            ||.          :||..|.||:.:.....:|....|.|.|.||.:.:..:..::  .|...:.
  Fly   222 RLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEY--YCTKSMSV 284

  Fly   337 GFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKIITTSDGLKHYEPNRRQCYFQKERELRYFN 401
            |||:|:|.|.::.:||...|.:...:|..|.|.|........::..:.:.|:|.|..|.:|.|:.
  Fly   285 GFKVLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYR 349

  Fly   402 IYSQSNCELECLANFTLTKCGCVKFSMPR-NVNMPVCGDASLKCYNQAEDELLLREFTQGLVNAG 465
            .||:.||||||.|...|.:|.||.:.:|| :....|||....:|.::.:.|:
  Fly   350 TYSRKNCELECEAKLLLRECSCVLYYLPRIDPLARVCGPNDNQCTDRVQTEI------------- 401

  Fly   466 ENTRGETEC-NCLPSCTSIAYEAEISQADF--DYKTVINTDSPEGKEEQSKRQGMKMSRVSIFFK 527
            |::.....| ||.|.|..:.|.|.:|.|..  |.:.....:.||...........::|.:..::.
  Fly   402 ESSLTNLSCENCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIFHGPYSNASEISILHFYYM 466

  Fly   528 EAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELIYFCTVR---LISNLRMRRKTRKEL 589
            ...|.::.:||::|.|:||:|.|||||||||.|:.|::|:.::.|||   ....||.|.|.|.|.
  Fly   467 TNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQ 531

  Fly   590 L 590
            |
  Fly   532 L 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	139/528 (26%)
ppk28	NP_573169.2	ASC	43..509	CDD:279230	139/528 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456753
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900