DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk26 and Asic3

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_038963092.1	Gene:	Asic3 / 286920	RGDID:	708578	Length:	564	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	118/562 - (20%)
Similarity:	193/562 - (34%)	Gaps:	143/562 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IKYGSGFQAAK----AIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIW 118
            :|..||.:.|:    :.|..:....|:||:.::.......|.|..|.:.::||      |...::
  Rat     1 MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLS------LAAFLY 59

  Fly   119 DKWNNNPVIVSFAEKST----PVWQIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVD 179
            ...........|..|:|    ...|:.|||||:|.....||       |.....|.....:.::.
  Rat    60 QVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRR-------SRLTPNDLHWAGTALLG 117

  Fly   180 LSDKQKGLY-GAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRNSPVKCS- 242
            |...:...| .|:.|...|.      |.......::...........:|..|:|::|..|  |.
  Rat   118 LDPAEHAAYLRALGQPPAPP------GFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQP--CGP 174

  Fly   243 DIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRV 307
            :.|....|..|.|::|||                               ..:.|...|:|
  Rat   175 ENFTVIFTRMGQCYTFNS-------------------------------GAHGAELLTTP----- 203

  Fly   308 LGPGARAGLYLFMGGAEIDF----DDMCRGPVQ-GFKILLHT---------------PGDVAQVS 352
             ..||..||.:.:...:.::    .||...|.: |.::.:|:               ||....||
  Rat   204 -KGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVS 267

  Fly   353 KQYFRI-----PFDQEVLISIRPKII--TTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCEL 410
            .|..::     |:......|:.|...  ..||.|....|             |....||...|.|
  Rat   268 CQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRP-------------RPSPPYSLIGCRL 319

  Fly   411 ECLANFTLTKCGCVKFSMPRNVNMPVCGDASLK-CYNQAEDELLLREFTQGLVNAGENTRGETEC 474
            .|.:.:...||||....||.  |.|||.....| |.:.|.|.:|.::                .|
  Rat   320 ACESRYVARKCGCRMMHMPG--NSPVCSPQQYKDCASPALDAMLRKD----------------TC 366

  Fly   475 NCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSRVS-------IFFKEAQFL 532
            .|...|.:..|..|:|        ::...|.......:::.....|.::       |||:...:.
  Rat   367 VCPNPCATTRYAKELS--------MVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYE 423

  Fly   533 TSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELI-YFCTV 573
            ...:...|..::.|.:.||.:|||:|.|:|:|:|:: |.|.|
  Rat   424 AVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEV 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	110/537 (20%)
Asic3	XP_038963092.1	ASC	17..547	CDD:413546	114/546 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920