Protein Alignment ppk26 and Asic2

DIOPT Version :10

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_037024.2
• Gene: Asic2 / 25364
• RGDID: 2017
• Length: 563
• Species: Rattus norvegicus
• Alignment Length: 581
• Identity: 137/581 - (23%)
• Similarity: 217/581 - (37%)
• Gaps: 186/581 - (32%)

  Fly    78 TTIHGIRYL--------GEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVI--VSFAE 132
            |.:||:|::        |..:|    |..|    ||:..|.:.|.|:    |::|.::  :|| .
  Rat    64 TKLHGLRHMCAGRTAAGGSFQR----RALW----VLAFCTSLGLLLS----WSSNRLLYWLSF-P 115

  Fly   133 KSTPV---W--QIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVS 192
            ..|.|   |  |:||||||||.....|....:..|.|     :..:..|::           ..:
  Rat   116 SHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLY-----YAGHWLGLL-----------LPN 164

  Fly   193 QVCEPHLHDVTLGNKTRRG--MEIIDALTEVSP-HF---------------DDTYLNCKWRN--- 236
            :...|.:.::..|::.||.  .::.|....:.| ||               :|..|:||:|.
  Rat   165 RTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELC 229

  Fly   237 SPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTS 301
            .|...|.:|.|:    |.|:.|||                             .|||       .
  Rat   230 GPHNFSSVFTKY----GKCYMFNS-----------------------------GEDG-------K 254

  Fly   302 PYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPV----------QGFKILLHTPGDVAQVSKQYF 356
            |....|.| |...||.:.:   :|..|:..  |:          .|.|:.:|:..:.
  Rat   255 PLLTTVKG-GTGNGLEIML---DIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEP-------- 305

  Fly   357 RIPFDQEVLISIRPK----IITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFT 417
              ||.||:...:.|.    :.|....|.:..|...:|. ..|..|.:|.:||.:.|.::|...:.
  Rat   306 --PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYI 367

  Fly   418 LTKCGCVKFSMPRNVNMPVCGDASLKCYNQ----AEDEL-LLREFTQGLVNAGENTRGETECNCL 477
            :..|.|      |.|:||  |||......|    ||..| ||.|            :....|.|.
  Rat   368 VENCNC------RMVHMP--GDAPFCTPEQHKECAEPALGLLAE------------KDSNYCLCR 412

  Fly   478 PSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR----VSIFFKEAQFLTSRRSE 538
            ..|....|..|:|......||     |.:..|::..:....:|.    :.|||:...:.|..:.:
  Rat   413 TPCNLTRYNKELSMVKIPSKT-----SAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKK 472

  Fly   539 LYGTTDFLANCGGLLGLFMGVSMLSIVEL---IYFCTVRLISNLRMRRKTRKELLKAVNKD 596
            .|.....|.:.||.:|||:|.|:|:|:||   ||    .||         :::||..:.|:
  Rat   473 AYEVAALLGDIGGQMGLFIGASLLTILELFDYIY----ELI---------KEKLLDLLGKE 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:459966	131/553 (24%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	137/581 (24%)