DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and asic-1

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_491214.3	Gene:	asic-1 / 191422	WormBaseID:	WBGene00022815	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	703	Identity:	142/703 - (20%)
Similarity:	222/703 - (31%)	Gaps:	303/703 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SDDS--EDEVDTKKQI-KYGSGFQAAKAI-----------IHE--------------YCDYTTIH 81
            |||.  |:|:|:|..| .:|:.||....:           :||              :|:.|..|
Worm   267 SDDMDLEEEIDSKTCICHHGNCFQIKGNVKKRKRRTPERKVHERLLSRYEGLLAVYSHCNCTKQH 331

  Fly    82 GIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVIVSF-AEKSTPVWQIPFPAV 145
            |                           ||..::...|..|:|...:.| .:|:..:|.
Worm   332 G---------------------------CVSTSVPDMDLENSNKTCLCFYNKKNEQIWP------ 363

  Fly   146 TVC---PETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVSQVC-----------E 196
              |   ||.:.|             :..:.|..|....|||.|  ...:|.:|           .
Worm   364 --CYKEPEWEER-------------KCSRCNTMGDCVYSDKPK--KQTISCLCATPIKMCVRIDP 411

  Fly   197 PHLHDVTL---------------------------------GNKTR-----RGME----IIDALT 219
            |..:|.:|                                 |.|.|     :.||    .:||||
Worm   412 PQTNDTSLDDRVVKFWDIQPSTTMSPIVKKKEERDKAYGYTGVKDRIALRAKAMENMIFAVDALT 476

  Fly   220 EVSPHFDDTYLNCKWRNS------PVKCS------DIFHKFV----TEDGVCFSF--------NS 260
            |..          ||:.|      .:|||      ::.|.||    ...|.||::        |.
Worm   477 EEE----------KWKISYNKSDFIMKCSFNGRECNVKHDFVEYLDPTYGACFTYGQKLGNNTNE 531

  Fly   261 LS-PA-----EIF----------RAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLG 309
            .| ||     |:|          .|.|:          ||::.         :.|..|:|: .||
Worm   532 RSGPAYGLRLEVFVNVTEYLPTTEAAGV----------RLTVH---------ATDEQPFPD-TLG 576

  Fly   310 PGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTP-GDVAQVSKQYFRIPFDQEVLISIRPKII 373
            ..|..|   |:....|....|.|.|         .| ||..:..|
Worm   577 FSAPTG---FVSSFGIKLKSMVRLP---------APYGDCVREGK-------------------- 609

  Fly   374 TTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCG 438
             |.|.:          |.||        .|:...|:..|:.......||              ||
Worm   610 -TEDFI----------YTQK--------AYNTEGCQRSCIQKHLSKTCG--------------CG 641

  Fly   439 DASLKCYNQAE----DELLLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQADFDYKTV 499
            |.....|.:::    |:...||..:..::.......:..|:|...|....|....|.:.:.....
Worm   642 DPRFPPYRESKNCPVDDPYKRECIKNEMHVATRDSKKLGCSCKQPCNQDVYSVSYSASRWPAIAG 706

  Fly   500 INTDSPEG---------KEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTTDFLANCGGLLGL 555
            ..:..|.|         |.||.       |.:.::|::..:.:...||.||.::.|::.||.|||
Worm   707 DLSGCPLGMAAHHCLNYKREQG-------SMIEVYFEQLNYESLLESEAYGWSNLLSDFGGQLGL 764

  Fly   556 FMGVSMLSIVELIYF---CTVRLISNLRMRRKTRKELLKA---------VNKD 596
            :||||:::|.|:..|   ..:.|||:.|.:|:..::...:         :|||
Worm   765 WMGVSVITIGEVACFFFEVFISLISSNRTKRRPARKSFSSSLRCSTDYNLNKD 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	120/606 (20%)
asic-1	NP_491214.3	deg-1	16..779	CDD:273309	133/663 (20%)
		ASC	17..>104	CDD:279230
		ASC	<469..788	CDD:295594	89/420 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820