DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and del-4

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_492230.2	Gene:	del-4 / 189033	WormBaseID:	WBGene00012116	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	119/569 - (20%)
Similarity:	207/569 - (36%)	Gaps:	135/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLS----VFTCVKLTLNIWDKWNNNPVIV 128
            |.:..::..:|:.||:.::|......| |.|||.|:|:|    ::..:.|..|......|....:
Worm     9 KYVFTDFSCWTSTHGVPHIGMANARWL-RAFWILVVVVSIALFIWQFITLLTNYLSFSVNTETTL 72

  Fly   129 SFAEKSTPVWQIPFPAVTVC-------PETKT-RREIFNFTDSYHQVRDFQSNVSGIVDLSDKQK 185
            .|||::       ||.||:|       .|||: ..::....|:|:.            |.|..|.
Worm    73 QFAERT-------FPTVTICHLNPWKLSETKSVDPDMSALIDAYNS------------DSSSAQF 118

  Fly   186 GLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRNSPVKCSDIFHKFVT 250
            ||..:::...:......||....|...:..:...:::..:||..::|.:.......:| |:.|..
Worm   119 GLPASLTADRQQQASKWTLMYSERLNEKQYNDAADIAYSYDDMVVSCTYNAKTCNITD-FNDFYN 182

  Fly   251 ED-GVCFSFNSLSPAEIFRAEGIIP-DFIFREENRLSMDWNVEDGYSAS---ADTSPYPNRVLGP 310
            .. |.|..||:.......||..:.. ..:.|.:....:.|....|....   .|..|||: |.|.
Worm   183 PSYGNCLQFNTDGMYSSSRAGPLYGLRMVMRTDQDTYLPWTEASGVIIDIHMQDEIPYPD-VFGY 246

  Fly   311 GARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKIITT 375
            .|..|....:|.:.:                     ...::||.|..        .:.:.|:.||
Worm   247 FAPPGTASSLGVSYV---------------------QTTRLSKPYGS--------CTTKTKLKTT 282

  Fly   376 SDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCV--KFSMPRNVNMPVCG 438
                                  .|...|:...|...|:....:..|||.  .:|...|....|..
Worm   283 ----------------------HYTGTYTVEACFRSCMQEKIIASCGCYYPAYSHASNTTQYVSC 325

  Fly   439 D------ASLKCYNQAEDELLLREFTQGLVNAGENTRGE--TECNCLPSCTSIAYEAEISQA--- 492
            |      ::|.|.:              |:|:.::|..:  |:|:|...|...:|...:|.|
Worm   326 DNGVQTLSNLNCVD--------------LINSADSTEFDVLTDCDCPQPCEIDSYGVTVSTAQWP 376

  Fly   493 -DFDYKTVINTDSPEGKEEQSKRQGMKMSR-----VSIFFKEAQFLTSRRSELYGTTDFLANCGG 551
             |....|..|...|.|..:.|....:...:     :.|:::...|.....|..|...:|:::.||
Worm   377 SDSYVPTECNPGGPSGPWDASGESCLDWYKANTILIEIYYERMNFQVLTESPAYTFVNFISDVGG 441

  Fly   552 LLGLFMGVSMLSIVE------LIYF--CTVRL----ISNLRMRRKTRKE 588
            .:|||:|:|::|.:|      |::|  ||.:.    |..|.|..|..|:
Worm   442 QVGLFLGMSIISAIEYLVLIFLVFFYCCTHKSRRAEIEQLEMDIKKAKD 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	110/537 (20%)
del-4	NP_492230.2	ASC	8..466	CDD:295594	111/543 (20%)
del-4	NP_492230.2	deg-1	14..460	CDD:273309	109/532 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820