DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and acd-1

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_491295.2	Gene:	acd-1 / 182852	WormBaseID:	WBGene00016064	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	599	Identity:	127/599 - (21%)
Similarity:	220/599 - (36%)	Gaps:	149/599 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KQIKYGSGFQAAKAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDK 120
            |:::...|..:.|.....:|:.||:||.:.:.:.||  ...|||:.::..|:...:.....:..:
Worm    65 KKLRKLEGTVSIKRETQHFCETTTMHGPKRIFQGKR--WATLFWLIMVSCSLGLLITQVFILASE 127

  Fly   121 WNNNPVI--VSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSN--------VS 175
            :.:.|.:  |||.....   .:.||.:|:|.....|:...|..:...:|.....|        :.
Worm   128 YLSKPTVSDVSFLINED---GMDFPLITICNLNPIRKTYVNEINKTGEVSPPMINYMMKWFTEIP 189

  Fly   176 GIVDLSDKQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRNSPVK 240
            .::..:|:             |.||:   ||:        :....:..|.:.| ::..:.||...
Worm   190 TLIGGADR-------------PTLHE---GNE--------ELKLYMKNHLNFT-VDSFFMNSGFS 229

  Fly   241 CSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPN 305
            |.||| |..:..|..|...:|| .|:....|          ...::|        .|:.|....:
Worm   230 CPDIF-KLCSFQGEIFDCCTLS-TEVLTPLG----------KCFTLD--------LSSSTKASMH 274

  Fly   306 RVLGPGARAGLYLFMGG-AEIDFDD-------MCRGPVQGFKILLHTPGDVAQVSKQYF------ 356
            :...||.:|||.:.:.. .|..||.       .....|.||:..:|.|..:..:|...|
Worm   275 KQTEPGIQAGLAITLDAHLEEQFDGSNGMDALFTNSFVNGFRYFVHPPNTIPHLSSDEFTVSPNT 339

  Fly   357 ----RIPFDQEVLISIRPKIITTS---DGLKHYEPNRRQCYFQKERELRYFNI-YSQSNCELECL 413
                .|..|:.||:........|.   ||::.                   |: ||..||...|.
Worm   340 VAFSAISSDRYVLLPTHQWGNCTENFPDGIQS-------------------NLSYSSGNCLSLCK 385

  Fly   414 ANFTLTKCGCVKFSMPRNVNMPVCGDASLKCYNQAEDELLLREFTQGLVNAGENTRGET------ 472
            |.|.:..|||.    |...|:    :.:||       |....|.|..|.|.......||
Worm   386 AKFYMENCGCT----PALYNI----ENNLK-------ECTPYETTTCLDNILAKPNKETGKIEFQ 435

  Fly   473 --ECN-CLPSCTSIAYEA------EISQADFDYKTVINTDSPEGKEEQSKRQGMKMSRVSIFFKE 528
              .|. |...|.|:.|.|      :.|...|.|...||.:..:|    ..|...:|  ::||:::
Worm   436 TPNCKACAQQCNSLVYRAYNSYGSQFSAGAFHYLKSINPEWTDG----HMRANFQM--INIFYRD 494

  Fly   529 AQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELIYFCTVRL-----------ISNLRMR 582
            ..:....:.:....|..|::.||.:|:|:|:|:::|.|:..|.:...           :.:.|:.
Worm   495 MSYTEYNQVQDASVTQLLSDIGGNMGMFLGMSVITITEICLFFSKMFWLGFSKKRRDYMYSKRVN 559

  Fly   583 RKT-RKELLKAVNK 595
            .|| .:|:.:.|.|
Worm   560 EKTHEREVCETVEK 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	117/542 (22%)
acd-1	NP_491295.2	ASC	83..536	CDD:279230	117/542 (22%)
acd-1	NP_491295.2	deg-1	83..536	CDD:273309	117/542 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14160
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920