DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk26 and del-1

DIOPT Version :9

Sequence 1:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001355359.1	Gene:	del-1 / 181534	WormBaseID:	WBGene00000952	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	722	Identity:	145/722 - (20%)
Similarity:	237/722 - (32%)	Gaps:	225/722 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LMARMAPAFRET--------------------VSDDSE-DEVDTKKQIKYGSGFQAAKAIIHEYC 75
            |:.|....:|||                    ..|||. .|...|.||::.         :.::|
Worm    22 LLRRNEERYRETEALVKKFKKKEEKEKDVGKSFEDDSPCKEEAPKTQIQHS---------VRDFC 77

  Fly    76 DYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFA---EKSTPV 137
            :.||.||:..:.......: |..|:.|.::.:..|:....::.||::....||:..   |.:
Worm    78 EQTTFHGVNMIFTTSLYWV-RFLWVVVSLVCICLCMYSFSHVKDKYDRKEKIVNVELVFESA--- 138

  Fly   138 WQIPFPAVTVCPETKTRR-------EIFNFTDSYHQVRDFQSNVS-------GIVDLSD------ 182
               ||||:|||.....:.       ||....|::||...:.::.:       |...|:|
Worm   139 ---PFPAITVCNLNPFKNHLARSVPEISETLDAFHQAVVYSNDATMDELSGRGRRSLNDGPSFKY 200

  Fly   183 -KQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNC----KWRNS--PVK 240
             :.:.:|...|  |.|...:........|.:|.. .:.....| |.:...|    .|..|  | :
Worm   201 LQYEPVYSDCS--CVPGRQECIAQTSAPRTLENA-CICNYDRH-DGSAWPCYSAQTWEKSICP-E 260

  Fly   241 CSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDF--------IFREENRLSMDWNVED----- 292
            |:||        |.|...|:       ...|.||.:        :|:.|:|:...|..:.
Worm   261 CNDI--------GFCNVPNT-------TGSGNIPCYCQLEMGYCVFQPESRVRRIWEFQGNKIPE 310

  Fly   293 ----------------GYSASAD----TSPYPNRV------LGPGARAGL--------------- 316
                            ||....|    |:....::      |.|..||.|
Worm   311 KGSPLRKEYMEQLTQLGYGNMTDQVAITTQAKEKMILKMSGLHPQRRAALGYGKSELIKMCSFNG 375

  Fly   317 --------------------YLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFD 361
                                |.|....|........||..|.::::...      |..|......
Worm   376 QQCNIDTEFKLHIDPSFGNCYTFNANPEKKLASSRAGPSYGLRLMMFVN------SSDYLPTTEA 434

  Fly   362 QEVLISIR---------------PKIITTSDGLKHYEPNR-RQCY---FQKE----RELRYFNIY 403
            ..|.|:|.               |..:.:|.|:.....|| .|.|   .||:    |.:.....|
Worm   435 TGVRIAIHGKEECPFPDTFGYSAPTGVISSFGISLRNINRLPQPYGNCLQKDNPQSRSIYKGYKY 499

  Fly   404 SQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDA----SLKCYNQAEDELLLREFTQGLVNA 464
            ....|...|.....:.||||.....|:........|:    :|.|......:|..:|
Worm   500 EPEGCFRSCYQYRIIAKCGCADPRYPKPWKRSAWCDSTNTTTLNCLTTEGAKLSTKE-------- 556

  Fly   465 GENTRGETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQS-KRQGMKMSRVSIFFKE 528
                 .:..|.|:..|....|....|.|.:...::..:.....|:..| .|:...|  :.|::::
Worm   557 -----NQKHCKCIQPCQQDQYTTTYSAAKWPSGSIQTSCDNHSKDCNSYLREHAAM--IEIYYEQ 614

  Fly   529 AQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELIYF--------CTVRLISNLRMRRKT 585
            ..:...|.||.|...:.:|:.||..|||:|.|::|::|.::|        |..|     |.|:||
Worm   615 MSYEILRESESYSWFNLMADMGGQAGLFLGASIMSVIEFLFFAVRTLGIACKPR-----RWRQKT 674

  Fly   586 RKELLKA 592
              |||:|
Worm   675 --ELLRA 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:279230	122/627 (19%)
del-1	NP_001355359.1	deg-1	75..656	CDD:273309	122/628 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14160
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820