Protein Alignment ppk26 and Asic2

DIOPT Version :10

• Sequence 1: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 614
• Identity: 140/614 - (22%)
• Similarity: 220/614 - (35%)
• Gaps: 219/614 - (35%)

  Fly    78 TTIHGIRYL--------GEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVI--VSFAE 132
            |.:||:|::        |..:|    |..|    ||:..|.:.|.|:    |::|.::  :|| .
Mouse    64 TKLHGLRHMCAGRTAAGGSFQR----RALW----VLAFCTSLGLLLS----WSSNRLLYWLSF-P 115

  Fly   133 KSTPV---W--QIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVS 192
            ..|.|   |  |:||||||||.....|....:..|.|     :..:..|::           ..:
Mouse   116 SHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLY-----YAGHWLGLL-----------LPN 164

  Fly   193 QVCEPHLHDVTLGNKTRRG--MEIIDALTEVSP-HF---------------DDTYLNCKWRN--- 236
            :...|.:.::..|::.||.  .::.|....:.| ||               :|..|:||:|.
Mouse   165 RTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELC 229

  Fly   237 -----SPVKC-------SD---------------------IFHKFVTEDGVCFSFNSLSPAEIFR 268
                 |.|.|       ||                     :|.|:    |.|:.|||
Mouse   230 GPHNFSSVSCPPREPALSDPALPRSPEALRWAPGTGHQAPVFTKY----GKCYMFNS-------- 282

  Fly   269 AEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRG 333
                                 .|||       .|....|.| |...||.:.:   :|..|:..
Mouse   283 ---------------------GEDG-------KPLLTTVKG-GTGNGLEIML---DIQQDEYL-- 313

  Fly   334 PV----------QGFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPK----IITTSDGLKHYEP 384
            |:          .|.|:.:|:..:.          ||.||:...:.|.    :.|....|.:..|
Mouse   314 PIWGETEETTFEAGVKVQIHSQSEP----------PFIQELGFGVAPGFQTFVATQEQRLTYLPP 368

  Fly   385 NRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDASLKCYNQ-- 447
            ...:|. ..|..|.:|.:||.:.|.::|...:.:..|.|      |.|:||  |||......|
Mouse   369 PWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNC------RMVHMP--GDAPFCTPEQHK 424

  Fly   448 --AEDEL-LLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKE 509
              ||..| ||.|            :....|.|...|....|..|:|......||     |.:..|
Mouse   425 ECAEPALGLLAE------------KDSNYCLCRTPCNLTRYNKELSMVKIPSKT-----SAKYLE 472

  Fly   510 EQSKRQGMKMSR----VSIFFKEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVEL--- 567
            ::..:....:|.    :.|||:...:.|..:.:.|.....|.:.||.:|||:|.|:|:|:||
Mouse   473 KKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDY 537

  Fly   568 IYFCTVRLISNLRMRRKTRKELLKAVNKD 596
            ||    .||         :::||..:.|:
Mouse   538 IY----ELI---------KEKLLDLLGKE 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk26	NP_648125.3	ASC	74..570	CDD:459966	134/586 (23%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	140/614 (23%)