DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8560 and CG18417

DIOPT Version :9

Sequence 1:	NP_001261516.1	Gene:	CG8560 / 38830	FlyBaseID:	FBgn0035781	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	212/432 - (49%)
Similarity:	282/432 - (65%)	Gaps:	33/432 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVLLLASVALA-----VENYDGYKIYDIN--ARNAFEKQLLLRLSGNEAYDFFDLPRSLDASS-- 62
            |:|.|:.::|:     ...|:|||||:::  ||:....:.|..|..|.:|  :::...|:|.:
  Fly     6 VILALSCLSLSAGLQRTNKYEGYKIYEVSSEARSVAFSEALSELVKNASY--YEVFSELNAGNPG 68

  Fly    63 RVMVKPEDQEGFEHLLEKYGVNYSVINENFGESLRQERDENQ--------NQRLMNLRSAERSVS 119
            ::||.|.:|..|..|:|:..|.|.:||.|.|.:|.::.:.|:        |.||    ..||
  Fly    69 KIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETNRMLRHWFPYNGRL----GTER--- 126

  Fly   120 FKAFHRHAEINAYLDELAAAYPSRVSVQVAGKSYENRDIKTITITNGDGKTGKNVVFLDAGIHAR 184
               ::.|.|||.::::||..:|.||.::..|:|||.|.:|||||||||.:..|||:.:|.|.|||
  Fly   127 ---YYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRNKNVILVDGGFHAR 188

  Fly   185 EWIAHAGALYVIHQLVENFAANSELLKDFDWVILPVVNPDGYEYSHTT--TRMWRKTRKPISSAC 247
            |||:.|.|.|:|:|||.|...|::||.|||||||||||||||||:..:  ||||||||||.||.|
  Fly   189 EWISPAAATYLINQLVYNLEDNADLLLDFDWVILPVVNPDGYEYTQLSEDTRMWRKTRKPSSSDC 253

  Fly   248 YGTDANRNFDFHWGEVGASSYSCSDTFKGETAFSEPETQLIRDILLSLTGRGKFYLTLHSYGNYL 312
            .|||.||||||||.|.|||...|.:.:.|...|||||..::.|::.|...||:.||||||||:.:
  Fly   254 IGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVVGDLIHSYVDRGQMYLTLHSYGSLI 318

  Fly   313 LYPWGWTSALPSSWRDNDEVAQGGADAIKSATGTKYTVG-SSTNVLYAAAGGSDDYAFGVANFPV 376
            |||||||:|:|.:..|..|||..|..||:.||||.|.:| |:|.:.|||:|.||||||. |.||:
  Fly   319 LYPWGWTAAVPDTEEDLHEVAAAGQSAIQEATGTIYKIGPSATTINYAASGASDDYAFN-AGFPI 382

  Fly   377 SITMELPAGGTGFNPSTSQIEGFVSETWVGIKAMAQKVADKY 418
            |.|||||.|||||:|..|.|:..|.||||||.|||:||..||
  Fly   383 SFTMELPFGGTGFDPPASDIDSIVKETWVGIAAMARKVIQKY 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_001261516.1	Propep_M14	29..98	CDD:280416	22/72 (31%)
CG8560	NP_001261516.1	M14_CP_A-B_like	123..414	CDD:199844	170/293 (58%)
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	12/33 (36%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	170/293 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450337
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	1	1.000	-	-		H76534
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	11	10.700