DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8560 and CG18585

DIOPT Version :9

Sequence 1:	NP_001261516.1	Gene:	CG8560 / 38830	FlyBaseID:	FBgn0035781	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	151/430 - (35%)
Similarity:	230/430 - (53%)	Gaps:	28/430 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLFAVVLLLASVAL----AVENYDGYKIYDINARNAFEKQLLLRLSGNEAYDFFDLPRSLDAS 61
            :|.|.|.::.|.|..:    ..|.||.:::|.:..:|..:...:.::  .|....:::.:..|..
  Fly     3 LLWLLATLVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKI--GELTKKYNIWKEYDER 65

  Fly    62 SR---VMVKPEDQEGFEHLLEKYGVNYSVINENFGESLRQER-DENQNQRLMNLRSAERSVSFKA 122
            ||   :||.|.:...|:.||:...::..::.||.     ||| ||.|    :...:...:..:..
  Fly    66 SRQIDIMVSPGELNHFQELLKFNNISSELMIENV-----QERIDEEQ----VTPTADSATFGWTK 121

  Fly   123 FHRHAEINAYLDELAAAYPSRVSVQVAGKSYENRDIKTITITNGDGKTGKNVVFLDAGIHAREWI 187
            ::...||.|:|||:..||||.....:.|||||.|.|:.|.|::..|..|   :|:::.|||||||
  Fly   122 YYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAGNPG---IFIESNIHAREWI 183

  Fly   188 AHAGALYVIHQLVENFAANSELLKD-FDWVILPVVNPDGYEYSHTTTRMWRKTRKP-ISSACYGT 250
            ..|.|.:.|:||:.:..|:...|.| :||.|:||.|.||:||||...|||||||:| .::||.|.
  Fly   184 TSASATWFINQLLTSEDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNACIGA 248

  Fly   251 DANRNFDFHW-GEVGASSYSCSDTFKGETAFSEPETQLIRDILLSLTGRGKFYLTLHSYGNYLLY 314
            |||||||.:| ...|||...||:||.|:...||||.:.:.:.|..:..:...|::.||||.|||.
  Fly   249 DANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQYLLS 313

  Fly   315 PWGWTS-ALPSSWRDNDEVAQGGADAIKSAT-GTKYTVGSSTNVLYAAAGGSDDYAFGVANFPVS 377
            |:|.|: ..|.::.|...:.:..||||::.. ||.|..||:.:|||.|.|.|.|:.|......:.
  Fly   314 PYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATGTSVDWVFNELGKKIG 378

  Fly   378 ITMEL-PAGGTGFNPSTSQIEGFVSETWVGIKAMAQKVAD 416
            .|:|. ..|..||.....||.....|..||:.|:.:|..:
  Fly   379 YTIEYRDKGRYGFILPPVQIIPNCEELMVGMLALIEKTKE 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_001261516.1	Propep_M14	29..98	CDD:280416	13/71 (18%)
CG8560	NP_001261516.1	M14_CP_A-B_like	123..414	CDD:199844	122/296 (41%)
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	16/77 (21%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	122/295 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466993
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	11	10.750