DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8560 and ZC434.9

DIOPT Version :9

Sequence 1:	NP_001261516.1	Gene:	CG8560 / 38830	FlyBaseID:	FBgn0035781	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001251356.1	Gene:	ZC434.9 / 172908	WormBaseID:	WBGene00013895	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	448	Identity:	131/448 - (29%)
Similarity:	228/448 - (50%)	Gaps:	39/448 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVLLLASVALAVENYDG----YKIYDINARNAFEKQLLLRLSGNEAY--DFFDLPRSLDASSRVM 65
            :::|:::.|:..|..|.    :::...:|.:..:.:.|..:.....:  ||:..|..:...:.:|
Worm    12 LLILISAFAINAEIADDKPPKFQVLRAHATDVPQLKALRDIHERTQHDLDFWQTPSKVGHRADIM 76

  Fly    66 VKPEDQEGFEHLLEKYGVNYSVINENFGESLRQERDENQNQRLMNLRSAER---------SVSFK 121
            |..:..|..:.:|:...::|.||.|:.|:.:.::  |:...|..||..::|         ...|.
Worm    77 VDEDRMEWLDSVLKNSNISYDVIIEDVGKLILEK--EHGPPRFSNLLFSKRMHNEGGNRARYGFG 139

  Fly   122 AFHRHAEINAYLDELAAAYPSRVSVQVAGKSYENRDIKTITITNGDGKTGKNVVFLDAGIHAREW 186
            .:|.:..|..::.::...||.:..|...|.:.|.|.|:.|.|.:...:..|.:.::|.|||||||
Worm   140 EYHSYQTICDWMKDIERKYPDKAKVFTMGTTSEGRPIQGIKIGSQVWRNDKRIFWIDGGIHAREW 204

  Fly   187 IAHAGALYVIHQLVENFAANSELLKDFD---WVILPVVNPDGYEYSHTTT----RMWRKTRKPI- 243
            .|...||:.|.:|:.::..:|.:....|   :.||||.||||||||.:..    |:|||.|..:
Worm   205 AAVHTALWFIDRLIADYNDDSLVRAAVDRLNFYILPVANPDGYEYSRSDVSPMIRLWRKNRAGVV 269

  Fly   244 --------SSACYGTDANRNFDFHWGEVGASSYSCSDTFKGETAFSEPETQLIRDILLS--LTGR 298
                    ...|.|.|.|||:|:|:||.|:|:..||:.::|.:||||.||:.:||.|.|  |.|:
Worm   270 CKKDRWFRDRCCGGVDLNRNYDWHFGETGSSTDKCSEIYQGSSAFSESETRSMRDFLTSSELNGK 334

  Fly   299 GKFYLTLHSYGNYLLYPWGWT-SALPSSWRDNDEVAQGGADAIKSATGTKYTVGSSTNVLYAAAG 362
            ...::|||:|....::|:... .::|:...:...|.:....|:::..||||..|:.:::||.:||
Worm   335 IDAFITLHTYSQMWIHPYSHARKSVPADVAELQRVGRAAVAALENTYGTKYKFGTGSDILYPSAG 399

  Fly   363 GSDDYAFGVANFPVSITMELPAG---GTGFNPSTSQIEGFVSETWVGIKAMAQKVADK 417
            ||||:|.|.........:||..|   ..||.....|:.....|||.|||.:.:.|.::
Worm   400 GSDDWAKGTLRIKYVYLLELRPGEDVWDGFILDQHQLIPTAKETWNGIKVVIRAVTEQ 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_001261516.1	Propep_M14	29..98	CDD:280416	14/70 (20%)
CG8560	NP_001261516.1	M14_CP_A-B_like	123..414	CDD:199844	106/312 (34%)
ZC434.9	NP_001251356.1	Propep_M14	45..111	CDD:366995	13/67 (19%)
		M14_CP_A-B_like	141..454	CDD:349433	106/312 (34%)
		ShK	682..719	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920