DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8560 and T06A4.1

DIOPT Version :9

Sequence 1:	NP_001261516.1	Gene:	CG8560 / 38830	FlyBaseID:	FBgn0035781	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_871809.1	Gene:	T06A4.1 / 171669	WormBaseID:	WBGene00020281	Length:	606	Species:	Caenorhabditis elegans

Alignment Length:	429	Identity:	140/429 - (32%)
Similarity:	213/429 - (49%)	Gaps:	35/429 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AVEN------YDGYKIYDINARNAFEKQLLLRLSGNEA---YDFFDLPRSLDASSRVMVKPEDQE 72
            |:.|      |..:|:..||.......:.|..|..:.:   .||:..|.::.|...:.|.|.|..
Worm    19 AIHNTDDNAGYHNFKLIRINPETEGSVKYLRSLYEDPSPYELDFWQPPTNIGAIVDLTVAPADAP 83

  Fly    73 GFEHLLEKYGVNYSVINENFGESLRQERDENQNQRLMNLRSAERSVSFKAFHRHAEINAYLDELA 137
            .|...||...::|.|...:..:::..||..::      ..:.....::..::...||...:..|.
Worm    84 RFVKDLESKKISYIVAVNDLSKAIENERGSDK------FYNPVAGFAYDKYNSLEEIQTEMKRLK 142

  Fly   138 AAYPSRVSVQVAGKSYENRDIKTITITNGDGKTGKNV-VFLDAGIHAREWIAHAGALYVIHQLV- 200
            ..||:.:::...|:|:|||.:..:.||......|..: :::|||||||||||.|.|:|:.|:|:
Worm   143 KEYPTMITLIDIGQSHENRTLLVMKITGKRNPLGSKISMWIDAGIHAREWIAPATAMYIAHELLL 207

  Fly   201 --ENFAANSELLKDFDWVILPVVNPDGYEYSHTTTRMWRKTRKPISSA--------CYGTDANRN 255
              ||.|..::|:...|:.||||:||||||||....|||||.|.|...|        |.|.|.|||
Worm   208 GYENDATVAKLMDHIDFYILPVMNPDGYEYSREKNRMWRKNRSPAKCARQTFSTVCCSGVDLNRN 272

  Fly   256 FDFHWGEVGASSYSCSDTFKGETAFSEPETQLIRDILLSLTGRGKFYLTLHSYGNYLLYPWGW-T 319
            ||:.|...|:||..|.||:.|..||||||:|.:||.|...|...  :::||||....|.|:|. .
Worm   273 FDWFWASTGSSSDPCHDTYHGSAAFSEPESQAVRDFLEQNTPEA--FISLHSYSQMWLIPYGHRK 335

  Fly   320 SALPSSWRDN-DEVAQGGADAIKSATGTKYTVGSSTNVLYAAAGGSDDYAFGVANFPVSITMEL- 382
            .:.|..:... ..:|.....|:....||||.||:..:::|.|:|||.|:|.|....|.:..:||
Worm   336 QSYPQDYHTGLRPLALRATKALYELYGTKYQVGTGADLMYEASGGSHDWAKGQLKVPYAYLIELR 400

  Fly   383 PAG---GTGFNPSTSQIEGFVSETWVGIKAMAQKVADKY 418
            |..   |.||.....:|.....||:..||.:|.::..::
Worm   401 PKNTMMGHGFLLPEREIVPTGLETFESIKVVADELVAQF 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_001261516.1	Propep_M14	29..98	CDD:280416	16/71 (23%)
CG8560	NP_001261516.1	M14_CP_A-B_like	123..414	CDD:199844	118/308 (38%)
T06A4.1	NP_871809.1	Propep_M14	40..110	CDD:366995	14/69 (20%)
		M14_CP_A-B_like	128..435	CDD:349433	118/308 (38%)
		ShK	568..602	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970