DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8560 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_001261516.1	Gene:	CG8560 / 38830	FlyBaseID:	FBgn0035781	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	456	Identity:	143/456 - (31%)
Similarity:	225/456 - (49%)	Gaps:	68/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVLLLASVALAVENYDGYKIY-----DINA-----RNAFEKQLLLRLSGNEAYDFFDLPRSLDAS 61
            :.|..::|:|:.:::..|::.     |..|     :||.:..|....:|.:.:.|:|
Worm     9 IFLCFSAVSLSTQSFAVYRLLPKSQTDFQAIQRLYKNATDHDLNFWKTGKDKHGFWD-------- 65

  Fly    62 SRVMVKPEDQEGFEHLLEKYGVNY-SVINENFGESLRQERDENQNQRLMNL------RSAERSVS 119
              |||..::.:.|...|:...::| ..|::..|...:.|    .|:.|.|:      .|:.....
Worm    66 --VMVDMKNSKYFLDFLQVNDISYIKTIDDVEGLITKHE----NNKTLSNMFPRLWDDSSSAHYD 124

  Fly   120 FKAFHRHAEINAYLDELAAAYPSRVSVQVAGKSYENRDIKTITITNGDGKTGKNVVFLDAGIHAR 184
            |..:..:..:..::.:|...||..|.....||:.|.|:|..:.| .||.:| |.:.::|.|||||
Worm   125 FHTYGSYQRMTDWMKQLVVKYPKMVQYISIGKTTEGRNIDGVEI-GGDSRT-KKIFWIDGGIHAR 187

  Fly   185 EWIAHAGALYVIHQLVE--NFAANSELLKDFDWVILPVVNPDGYEYSHTTT----RMWRKTRKPI 243
            ||.|...||:.||||..  |.....:||.:..:|::|.:||||||::.::|    |:|||.|..:
Worm   188 EWAAPHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKM 252

  Fly   244 ---------SSACYGTDANRNFDFHWGEVGASSYSCSDTFKGETAFSEPETQLIRDILLS--LTG 297
                     :..|.|.|.|||||||:.|.|.|...||:.::|.:.|||||.:.:||.|||  ..|
Worm   253 QCRKDIWGRNRCCRGVDLNRNFDFHFRESGTSDDPCSEIYQGPSPFSEPEAKAVRDALLSQRYKG 317

  Fly   298 RGKFYLTLHSYGNYLLYPWGW-TSALPSSWRDNDEVAQGGADAIKSATGTKYTVGSSTNVLYAAA 361
            |...|:|||:|....::|:|. ..|.|...:|..||.:..|.|:|...||||.|||..:.||.|:
Worm   318 RTDAYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRVYGTKYVVGSGADTLYPAS 382

  Fly   362 GGSDDYAFGVANFPVSITMELPAGGTGFNPSTSQIEGFV----------SETWVGIKAMAQKVAD 416
            |||:|:|...|.......:||       .|.....:||:          .|||.|::.:|:.|.|
Worm   383 GGSEDWAKHEAKVKFVYLLEL-------RPDEKNWDGFILDEKELIPTARETWEGVRVVAEAVLD 440

  Fly   417 K 417
            :
Worm   441 R 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_001261516.1	Propep_M14	29..98	CDD:280416	15/74 (20%)
CG8560	NP_001261516.1	M14_CP_A-B_like	123..414	CDD:199844	115/318 (36%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	16/76 (21%)
		M14_CP_A-B_like	128..438	CDD:349433	115/318 (36%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.980