DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8560 and Y18H1A.9

DIOPT Version :9

Sequence 1:	NP_001261516.1	Gene:	CG8560 / 38830	FlyBaseID:	FBgn0035781	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_490776.2	Gene:	Y18H1A.9 / 171666	WormBaseID:	WBGene00021213	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	144/441 - (32%)
Similarity:	227/441 - (51%)	Gaps:	34/441 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVLLLASVALAVENYDGYKIYDINARNAFEKQLLLRLSGNEA-YDFFDLPRSLDASSRVMVKPED 70
            :||:...|...:.:...:.::.:......:..:|..|..|:. .||:..|........||:..|.
Worm     4 IVLIGLVVPSVLAHQKKFTVWRVQPTTQDQVDILHNLYLNDVKLDFWKSPSEAGKEVHVMISDEK 68

  Fly    71 QEGFEHLLEKYGVNYSVINENFGESL---RQERDENQNQ-RLMNLRSAERSVSFKAFHRHAEINA 131
            .:.|...|:.:.:.:||:.::..:.:   :::||:.:.| ||.:.|..:...:...:|..|::..
Worm    69 TQQFMKELDDHSIKHSVMIDDVQKVIVEQKEKRDKLRKQVRLHDWREQKVQFNLAQYHSFADVIN 133

  Fly   132 YLDELAAAYPSRVSVQVAGKSYENRDIKTITITNGDGKTGKNVVFLDAGIHAREWIAHAGALYVI 196
            ||:.||..||..||||..|.::|.|.|..|.|||......|..:::|.|||||||::.:..||.|
Worm   134 YLNSLAITYPELVSVQPIGTTHEGRQIPLIKITNKRNGGTKRGIWVDGGIHAREWVSPSTVLYFI 198

  Fly   197 HQLVENFAANSELLKDF----DWVILPVVNPDGYEYSHTTT----RMWRKTRK------------ 241
            ||||..:..:.: :|.|    :|.|:|::||||||||.::.    |:|||.|.
Worm   199 HQLVTQYDKDVQ-IKQFVDQLEWYIVPLLNPDGYEYSRSSNDPEIRLWRKNRSPPKCIQQATGLF 262

  Fly   242 --PISSACYGTDANRNFDFHWGEVGASSYSCSDTFKGETAFSEPETQLIRDILLSLTGRGKFYLT 304
              |.::.|.|.|.|||||:.:|:||:|:..||:.::|..|||||||..:||.:  ...|...:||
Worm   263 QPPTTTCCQGVDLNRNFDWFFGQVGSSTDPCSEIYQGAYAFSEPETAAVRDFV--QRHRISTFLT 325

  Fly   305 LHSYGNYLLYPWG-WTSALPSSWRDNDEVAQGGADAIKSATGTKYTVGSSTNVLYAAAGGSDDYA 368
            .|||...|:||:| ......:...|....|...|.|:.|...|:|.||:..:.||.|:|||:|:|
Worm   326 FHSYSQILMYPFGHQVRTYSNDLNDLRSTALSAAQALNSVYNTQYKVGTGADTLYPASGGSEDWA 390

  Fly   369 FGVANFPVSITMEL-PAGGT--GFNPSTSQIEGFVSETWVGIKAMAQKVAD 416
            .|.|:...|...|| |....  ||..:.:||.....|||..:|.:|.|..:
Worm   391 KGKAHVKYSFLFELRPEEQVWDGFLLAENQIIPTARETWEAVKVIASKTIE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8560	NP_001261516.1	Propep_M14	29..98	CDD:280416	13/72 (18%)
CG8560	NP_001261516.1	M14_CP_A-B_like	123..414	CDD:199844	121/316 (38%)
Y18H1A.9	NP_490776.2	Propep_M14	29..97	CDD:366995	13/67 (19%)
		M14_CP_A-B_like	125..436	CDD:349433	120/313 (38%)
		ShKT	454..487	CDD:214586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.880