DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRT33A and LamC

DIOPT Version :9

Sequence 1:	NP_004129.2	Gene:	KRT33A / 3883	HGNCID:	6450	Length:	404	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	114/416 - (27%)
Similarity:	184/416 - (44%)	Gaps:	97/416 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    56 EKETMQFLNDRLASYLEKVRQLERDNAELE---NLIRERSQQQEPLVCASYQSYFKTIEELQQKI 117
            |||.:|.||||||.|::::|.||.:|:.|.   ||.::...::...:.|.|:.......:|..:
  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDE- 109

Human   118 LCSKSENARLVVQIDNAKLASDDFRTKYETELSLRQLVE----------SDING----------- 161
              :..|.|:|.:.|......:||.:.:.:.:.....:.|          :::||
  Fly   110 --TAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKK 172

Human   162 --------------LRRILDEL-------TLCRSDLEAQVESLKEELLCLKQNHEQEVNTLR--- 202
                          |||.||:|       ||.|.|||.|.:||:|||....|.|.||:...|
  Fly   173 FEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRR 237

Human   203 ----CQLGDRLNVEVDAAPTVDLNQVLNETRSQYEALVETNRREVEQWFATQTEELNKQVVSSSE 263
                .::..||:.:.:|    .|.|.|.|.|.|||..:..||.|:|..:..:.:.| |...:.:.
  Fly   238 QIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNL-KAAANRAA 297

Human   264 QLQSYQAEIIELRRT-VNALEIELQAQHNLRDS----------LENTLTESEARYSSQLSQVQRL 317
            |..:...|.:.|.|| ::.|..:||   ||.|:          |||.|.....|::       :.
  Fly   298 QGSALATEEVRLMRTKIDGLNAKLQ---NLEDTNAGLNARIRELENLLDTERQRHN-------QY 352

Human   318 ITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKL----PSNPCATTNAC 378
            |.::|::|..:|.::..|.||||.|:|::..|:.||..|..||..|:.:|    |..|  ||::.
  Fly   353 IASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRP--TTDSG 415

Human   379 DKSTGPCIS----------NPCGLRA 394
            ..|.|..::          .|.|.|:
  Fly   416 ISSNGSHLTASASSRSGRVTPSGRRS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT33A	NP_004129.2	Head	1..56		114/416 (27%)
		Filament	55..366	CDD:278467	104/372 (28%)
		Coil 1A	57..91		17/36 (47%)
		Linker 1	92..102		0/9 (0%)
		Coil 1B	103..203		34/148 (23%)
		Linker 12	204..219		3/14 (21%)
		Coil 2	220..363		47/153 (31%)
		Tail	364..404		10/45 (22%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	104/372 (28%)
		ATP-synt_B	<67..>142	CDD:304375	15/77 (19%)
		MreC	<178..>224	CDD:302802	18/45 (40%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910