Protein Alignment CG18417 and CPA4

DIOPT Version :10

• Sequence 1: NP_648119.1
• Gene: CG18417 / 38829
• FlyBaseID: FBgn0035780
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_057436.2
• Gene: CPA4 / 51200
• HGNCID: 15740
• Length: 421
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 138/440 - (31%)
• Similarity: 225/440 - (51%)
• Gaps: 50/440 - (11%)

  Fly     5 WVILALSCLSLSAGLQRTNKYEGYKIYEVSSEARSVAFSEALSELVKN----ASYYEVFSELNAG 65
            | ||.:..| :.:.:....|:.|.::..::  .|:......||:||.:    .::::..|..|
Human     3 W-ILFIGAL-IGSSICGQEKFFGDQVLRIN--VRNGDEISKLSQLVNSNNLKLNFWKSPSSFN-- 61

  Fly    66 NPGKIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETNRMLRHWFPYNGRLGTER---- 126
            .|..::|.......|...:....::|.:...::...|..:.:.   ::|      ..|.||
Human    62 RPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDE---MQH------NEGQERSSNN 117

  Fly   127 -----YYNHEEINQFIEDLAGEHP---RRVFLKTVGRSYEGRWLKTITITNGDARRNKNVILVDG 183
                 |::.|.|...::::|.:.|   |||   .:|.|:|.|.:..:..:.|...| :..:.::.
Human   118 FNYGAYHSLEAIYHEMDNIAADFPDLARRV---KIGHSFENRPMYVLKFSTGKGVR-RPAVWLNA 178

  Fly   184 GFHAREWISPAAATYLINQLVYNLEDN---ADLLLDFDWVILPVVNPDGYEYTQLSEDTRMWRKT 245
            |.|:|||||.|.|.:...::|.:.:.:   ..:|...|..:|||.|||||.|||  ...|:||||
Human   179 GIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQ--TQNRLWRKT 241

  Fly   246 --RKPSSSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVVGDLIHSYVD-RGQM 307
              |.|.|| |||.|||||::..:..:||||:||..:|.|....||.|...|.|.|..:.: :|
Human   242 RSRNPGSS-CIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKG-- 303

  Fly   308 YLTLHSYGSLILYPWGWTA-AVPDTEEDLHEVAAAGQSAIQEATGTIYKIGPSATTINYAASGAS 371
            ::.||||..|::||:|::. ..||.|| |.:||.....|:...:||.|::||:.||: |.|||:|
Human   304 FIDLHSYSQLLMYPYGYSVKKAPDAEE-LDKVARLAAKALASVSGTEYQVGPTCTTV-YPASGSS 366

  Fly   372 DDYAFNAGFPISFTMELPFGGT-GFDPPASDIDSIVKETWVGIAAMARKV 420
            .|:|::.|...:||.||...|| ||..||:.|....:|||:|:..:...|
Human   367 IDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHV 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<70..105	CDD:460505	4/34 (12%)
		Peptidase_M14	133..412	CDD:459730	112/289 (39%)
CPA4	NP_057436.2	Propep_M14	27..101	CDD:460505	12/77 (16%)
		M14_CPA	118..419	CDD:349442	116/310 (37%)