DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and CG2915

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_610338.1	Gene:	CG2915 / 35754	FlyBaseID:	FBgn0033241	Length:	453	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	141/460 - (30%)
Similarity:	221/460 - (48%)	Gaps:	65/460 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVVWVILALSCLSLSAGL--------QRTN-----KYEGYKIYEVSSEARSVAFSEALSELVKN 52
            :.::.|.:|.|..:|.:|:        .|.|     :|:.|:||.|..|               |
  Fly    18 LVILCVAMAASGTNLDSGICPVAGDSGCRGNPPDQARYDNYRIYNVEFE---------------N 67

  Fly    53 ASYYEVFSEL--------------NAGNPGKIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLS 103
            ....|:|.:|              ..|....|:|..|...:...|::...||:.:      ||.:
  Fly    68 QEQIELFQKLEEQSDSLTFIGHAREVGQKLSILVAAHRVADIADLLKTYKVKHRV------LTYN 126

  Fly   104 RQFETNRMLRHWFPYN---GRLGTERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTI 165
            .|.:.:|.|....|.:   .:|..:.:::.:.|.::::.:..::|.||.:..:|.|.:|..:|.:
  Fly   127 FQEKIDRNLAEVQPESIDASQLDWQHFFHLKTIYEWLDKMVEKYPNRVTVLDMGSSTQGNAIKGV 191

  Fly   166 TITNGDARRNKNVILVDGGFHAREWISPAAATYLINQLVYNLEDNA-DLLLDFDWVILPVVNPDG 229
            .:|   :..|...|.::.|.|||||||||||||:||||:.:.:... .|..|::|:|.|.|||||
  Fly   192 KLT---SNANNKAIFIESGIHAREWISPAAATYIINQLLTSQDPKVQQLAQDYNWIIFPCVNPDG 253

  Fly   230 YEYTQLSEDTRMWRKTRKPSSSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVV 294
            |:||  .|..|||||.|:...: |.|.|.|||:..|||..|:|.||....:||....||.|...:
  Fly   254 YKYT--FEHDRMWRKNRQLFGT-CRGVDLNRNYPDHWNSTGSSSDPTRYDFAGPSAGSELETKRL 315

  Fly   295 GDLIHSYVDRGQM--YLTLHSYGSLILYPWGWTAAVPDTEEDLHEVAAAGQSAIQEATGTIYKIG 357
            .|.|.:...:.|:  |:.||||..::::|:|:|.......:||.|......:||:...|..|..|
  Fly   316 IDFIRANAGKEQIKTYIALHSYSQMLMFPYGYTKERVSNYDDLQEFGKKASAAIKAENGRDYVSG 380

  Fly   358 PSATTINYAASGASDDYAFN-AGFPISFTMEL---PFGGTGFDPPASDIDSIVKETWVGIAAMAR 418
            ....|| |.:||.|.|:|.: ||.||::|.||   |.....|..||.:|.....|.:..|.|:..
  Fly   381 SLFETI-YPSSGGSMDWAHSEAGIPIAYTFELRGPPDSQDLFILPAVEIQPTASEAFTAIRAIVE 444

  Fly   419 KVIQK 423
            ...:|
  Fly   445 AAAEK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	7/33 (21%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	109/299 (36%)
CG2915	NP_610338.1	MpaA	50..433	CDD:225421	130/410 (32%)
		Propep_M14	63..133	CDD:280416	16/90 (18%)
		M14_CP_A-B_like	153..446	CDD:199844	109/299 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466972
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750