DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and CG7025

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_609133.2	Gene:	CG7025 / 34042	FlyBaseID:	FBgn0031930	Length:	429	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	152/423 - (35%)
Similarity:	227/423 - (53%)	Gaps:	23/423 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VILALSCLSLSA--GLQRTNKYEGYKIYEVSSEARSVAFSEALSELVKNASYYEVFSELNAGNPG 68
            ::|||..|:..|  |.....:|:.|.:|:|..|.:  |....|.:|.::...:.::.|  |.:..
  Fly     8 IVLALVVLAQGASFGQDERLRYDNYSVYKVKFETQ--AQRSILRKLAEDRENFRLWHE--AKDEL 68

  Fly    69 KIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETNRMLRHWFPYNGRLGTERYYNHEEI 133
            .:|:.|.........:::.||..::...||...:..:...|.....    :|..|..:|.:..||
  Fly    69 HLMLSPGAFGELETEIQKTNVTAELFISNVQELIDSEEAANLKASR----DGTFGWTKYNSLAEI 129

  Fly   134 NQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRNKNVILVDGGFHAREWISPAAATY 198
            ..:::|:...:|.......||:|||||.::.|.|:   .:.|...:|::...||||||:.|.||:
  Fly   130 YAWLDDILAAYPTITESFIVGQSYEGRTIRGIKIS---YKSNNPGVLIESNIHAREWITSATATW 191

  Fly   199 LINQLVYNLEDNA-DLLLDFDWVILPVVNPDGYEYTQLSEDTRMWRKTRKPSS-SDCIGTDPNRN 261
            |||:.:.:.::.. ||..:.||.|:||:|.||:.||.  |..|||||||:||. |.|||.|||||
  Fly   192 LINEFLTSTDELVRDLAENHDWYIVPVLNVDGFVYTH--EKDRMWRKTRQPSEISSCIGADPNRN 254

  Fly   262 FDFHWNE-EGASDDPCDNIYAGAKPFSEPEALVVGDLIHSYVDRGQMYLTLHSYGSLILYPWGWT 325
            :|.||.| ||||.:||...|.|.|||||||...:.:.:.|..|:..:.|..|||..|:|.|:|.|
  Fly   255 YDSHWMENEGASSNPCAEDYGGPKPFSEPEIQAMSEFVISIKDKINVLLAFHSYSQLLLSPYGHT 319

  Fly   326 -AAVPDTEEDLHEVAAAGQSAIQEAT-GTIYKIGPSATTINYAASGASDDYAFN-AGFPISFTME 387
             ...|...:|:.|||.|...|::... ||:|:.| ||..|.|.||||:.|:|:| .|..||:|:|
  Fly   320 KEEFPPNFDDMMEVAKAYGDAVESLPYGTVYRYG-SAAGILYPASGATIDWAYNEQGVEISYTIE 383

  Fly   388 L-PFGGTGFDPPASDIDSIVKETWVGIAAMARK 419
            . ..|..||..|...|....:|..:||||:..|
  Fly   384 FRDTGRYGFILPPVHIIPNAEEALIGIAALLEK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	5/33 (15%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	127/300 (42%)
CG7025	NP_609133.2	Propep_M14	36..103	CDD:280416	13/70 (19%)
CG7025	NP_609133.2	M14_CP_A-B_like	123..416	CDD:199844	126/298 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466986
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.700