DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and Y59C2A.1

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_494213.2	Gene:	Y59C2A.1 / 173577	WormBaseID:	WBGene00021984	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	455	Identity:	131/455 - (28%)
Similarity:	223/455 - (49%)	Gaps:	43/455 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TVVWVILALSCLSL----SAGLQRTNKYEGYKIY----EVSSEA--RSVAFSEALSELVKNAS-Y 55
            |:|.:::.::...:    ::|.:|.: |.||.::    :.||:.  :...:...|.:..:.|. .
Worm     5 TLVPILILVTTYGVNCHENSGEKRAD-YSGYTLHRFKVDTSSDTMEKLEGYDMQLDKTTQTARLL 68

  Fly    56 YEVFSELNAGNP-GKIMVHPHEQVNFVQL----------MEENNVKYDIINRNVGLTLSRQFETN 109
            .::::|.:..|| ..|:|.|.....|..|          |.|.:::..|......:..:......
Worm    69 IDIWAEPSKQNPYADILVAPEFLQKFKSLLTSAELSTLKMLEGDIQSQINAERHAMIRNSVRRRK 133

  Fly   110 RMLRHWFPYNGRLGTERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITI-TNGDAR 173
            |.::.|..::    |..|:::.|:.:|::.|:.:....|.:..|..|.|||.:..:.| ..|.:.
Worm   134 RAMKTWQEFD----TNAYHSYNEMVEFMKLLSEQKSDMVEMVKVATSSEGRSIYGVKIHPPGPSP 194

  Fly   174 RNKNVILVDGGFHAREWISPAAATYLINQLVYNLEDNADL---LLDFDWVILPVVNPDGYEYTQL 235
            ..|..|:||.|.||||||:||...::|.::|.....|..:   |..|||.|:|.||||||||::.
Worm   195 PEKPSIIVDAGVHAREWIAPAVGLFMIRKIVEEYGRNPQVTANLQKFDWYIMPQVNPDGYEYSRT 259

  Fly   236 SEDTRMWRKTRKPS---SSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVVGDL 297
            ::  |:|||||..:   :..|:|.|.|||:.:.|.|.||:..||.|||.|:.|:||||...:.:.
Worm   260 TD--RLWRKTRSKNVTVNRWCVGADANRNWGYRWGEAGANRTPCSNIYMGSHPYSEPEIRGLKEF 322

  Fly   298 IHSYVDRGQMYLTLHSYGSLILYPWGWTAAVPDTEEDLHEVAAAGQSAIQEATGTIYKIGPSATT 362
            ....:....:|::|||||.|:|.|||:|....:..:|....|.....||:..||..|..| :.:.
Worm   323 FTWQITNPMVYISLHSYGQLLLSPWGYTNERTENYQDQQNAAKEAAQAIKNTTGVSYSYG-TISE 386

  Fly   363 INYAASGASDDYAFNAGFPISFTMEL-----PFGGTGFDPPASDIDSIVKETWVGIAAMARKVIQ 422
            :.|.|||.|.|:..:.|.|..:.:||     | ....|:.|.|.|.:...|....:.|:....::
Worm   387 MMYPASGTSIDFMQHRGVPYIYGVELRPTDNP-NSFAFNLPPSYIRATGDEMLAALNAIGTHAVK 450

Fly 423 422
Worm 451 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	10/44 (23%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	106/304 (35%)
Y59C2A.1	NP_494213.2	Propep_M14	<69..120	CDD:366995	11/50 (22%)
Y59C2A.1	NP_494213.2	M14_CP_A-B_like	147..441	CDD:349433	105/297 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H76534
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.790