DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and ZC434.9

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001251356.1	Gene:	ZC434.9 / 172908	WormBaseID:	WBGene00013895	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	456	Identity:	129/456 - (28%)
Similarity:	232/456 - (50%)	Gaps:	44/456 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VWVILALSCLSLSAGL--QRTNKYEGYKIYEVSSEARSVAFSEALSELVK----NASYYEVFSEL 62
            :|:::.:|..:::|.:  .:..|::     .:.:.|..|...:||.::.:    :..:::..|::
Worm    10 LWLLILISAFAINAEIADDKPPKFQ-----VLRAHATDVPQLKALRDIHERTQHDLDFWQTPSKV 69

  Fly    63 NAGNPGKIMVHPHEQVNFVQLMEENNVKYDIINRNVG-LTLSRQFETNRMLRHWFP---YN---- 119
              |:...|||..........:::.:|:.||:|..:|| |.|.::....|.....|.   :|
Worm    70 --GHRADIMVDEDRMEWLDSVLKNSNISYDVIIEDVGKLILEKEHGPPRFSNLLFSKRMHNEGGN 132

  Fly   120 -GRLGTERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRNKNVILVDG 183
             .|.|...|::::.|..:::|:..::|.:..:.|:|.:.|||.::.|.|.:...|.:|.:..:||
Worm   133 RARYGFGEYHSYQTICDWMKDIERKYPDKAKVFTMGTTSEGRPIQGIKIGSQVWRNDKRIFWIDG 197

  Fly   184 GFHAREWISPAAATYLINQLVYNLEDNADLLLDFD---WVILPVVNPDGYEYTQ--LSEDTRMWR 243
            |.|||||.:...|.:.|::|:.:..|::.:....|   :.||||.|||||||::  :|...|:||
Worm   198 GIHAREWAAVHTALWFIDRLIADYNDDSLVRAAVDRLNFYILPVANPDGYEYSRSDVSPMIRLWR 262

  Fly   244 KTRK--PSSSD-------CIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVVGDLIH 299
            |.|.  ....|       |.|.|.|||:|:|:.|.|:|.|.|..||.|:..|||.|...:.|.:.
Worm   263 KNRAGVVCKKDRWFRDRCCGGVDLNRNYDWHFGETGSSTDKCSEIYQGSSAFSESETRSMRDFLT 327

  Fly   300 SYVDRGQM--YLTLHSYGSLILYPWGWT-AAVPDTEEDLHEVAAAGQSAIQEATGTIYKIGPSAT 361
            |....|::  ::|||:|..:.::|:... .:||....:|..|..|..:|::...||.||.| :.:
Worm   328 SSELNGKIDAFITLHTYSQMWIHPYSHARKSVPADVAELQRVGRAAVAALENTYGTKYKFG-TGS 391

  Fly   362 TINYAASGASDDYAFNA-GFPISFTMELPFGGTGFDPPASDIDSIV---KETWVGIAAMARKVIQ 422
            .|.|.::|.|||:|... .....:.:||..|...:|....|...::   ||||.||..:.|.|.:
Worm   392 DILYPSAGGSDDWAKGTLRIKYVYLLELRPGEDVWDGFILDQHQLIPTAKETWNGIKVVIRAVTE 456

  Fly   423 K 423
            :
Worm   457 Q 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	8/33 (24%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	102/313 (33%)
ZC434.9	NP_001251356.1	Propep_M14	45..111	CDD:366995	15/67 (22%)
		M14_CP_A-B_like	141..454	CDD:349433	102/313 (33%)
		ShK	682..719	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920