DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	466	Identity:	139/466 - (29%)
Similarity:	217/466 - (46%)	Gaps:	61/466 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VVWVILALSCLSLSAGLQRTNKYEGYKIYEVSSEARSVAFSEALSELVK--------NASYYEVF 59
            ::.|||||    |.|......::..:|::.|....     ::.|.::::        .|.::...
Worm     2 ILRVILAL----LIAVHSSCQEHGAFKVFRVLPTT-----NQQLLQMIRLFETADTDRADFWHAP 57

  Fly    60 SELNAGNPGKIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETN------------RML 112
            |.:|  ....|||.|.....|.|.:|::...:.:...::...|..: |.|            :.|
Worm    58 SVVN--GTVDIMVAPEHTDQFRQYLEKHGYTFQVAIDDLHKLLIEK-EGNLSTHSNDDAFFLKRL 119

  Fly   113 RHWFPYNGRLGTERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRNKN 177
            .....::.||....||::..::.::|.:|...|....|..||.:.|||  ..:.:..|....:|.
Worm   120 HDDVGFHSRLRMGEYYSYSVLSTWLERIAENMPDIAKLIKVGTTIEGR--DILGLKFGKDTPDKK 182

  Fly   178 VILVDGGFHAREWISPAAATYLINQLVYNLEDNADLLLDFDWVIL---PVVNPDGYEYTQLSED- 238
            ::::|.|.|||||.:...|:|.||.:|...|::..:....|.::|   ||:||||||||:..:.
Worm   183 IVVIDAGIHAREWAAIHTASYFINLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTN 247

  Fly   239 --TRMWRKTRKPS--------SSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALV 293
              .|||||:|.|.        :|.|:|.|.||||||.::|.|||..||..||.|...|||||:..
Worm   248 PRARMWRKSRSPKACAFDGVRNSCCMGVDLNRNFDFRFSEIGASRYPCSEIYHGPSAFSEPESKA 312

  Fly   294 VGDLIHSYVDRGQMYLTLHSYGSLILYPWG---WTAAVPDTEEDLHEVAAAGQSAIQEATGTIYK 355
            ....:.|...|.:.|:|||||..|.:|.:.   :|.| ||.|| ...|||.....:....||.|:
Worm   313 YSQFLTSLKGRLEAYITLHSYSQLWIYSYSHRKFTYA-PDIEE-TRRVAAKAVQELGRMYGTKYR 375

  Fly   356 IGPSATTINYAASGASDDYAFNA-GFPISFTMELPFG------GTGFDPPASDIDSIVKETWVGI 413
            .| :...|.||.||.|.|:|... ....|:|:||..|      ..||....:.:....||||.|:
Worm   376 HG-TGPEIIYAFSGGSTDWAKETLKIKYSYTIELRPGYEGIIEWNGFVLDKNQLIPTAKETWAGV 439

  Fly   414 AAMARKVIQKY 424
            ..:..:|..::
Worm   440 TVVLDEVTNQW 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	7/33 (21%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	112/316 (35%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	12/77 (16%)
		M14_CP_A-B_like	134..446	CDD:349433	112/316 (35%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810