DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18417 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	459	Identity:	146/459 - (31%)
Similarity:	227/459 - (49%)	Gaps:	59/459 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TVVWVILALSCLSLSAGLQRTNKYEGYKIYEVSSEARSVAFSEALSELVKNASYYEVFSELNAGN 66
            |.:.:.|..|.:|||     |..:..|::.     .:|....:|:..|.|||:.:    :||...
Worm     5 TSLLIFLCFSAVSLS-----TQSFAVYRLL-----PKSQTDFQAIQRLYKNATDH----DLNFWK 55

  Fly    67 PGK-------IMVHPHEQVNFVQLMEENNVKY-DIINRNVGLTLSRQFETNRMLRHWFPYNGRLG 123
            .||       :||.......|:..::.|::.| ..|:...||.  .:.|.|:.|.:.||   ||.
Worm    56 TGKDKHGFWDVMVDMKNSKYFLDFLQVNDISYIKTIDDVEGLI--TKHENNKTLSNMFP---RLW 115

  Fly   124 TE---------RYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRNKNVI 179
            .:         .|.:::.:..:::.|..::|:.|...::|::.|||.:..:.| .||: |.|.:.
Worm   116 DDSSSAHYDFHTYGSYQRMTDWMKQLVVKYPKMVQYISIGKTTEGRNIDGVEI-GGDS-RTKKIF 178

  Fly   180 LVDGGFHAREWISPAAATYLINQLVYNLEDNA--DLLLDFDWVILPVVNPDGYEYTQLSED--TR 240
            .:|||.|||||.:|..|.:.|:||.....:..  .||.:..:|::|.:||||||:|:.|.:  .|
Worm   179 WIDGGIHAREWAAPHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVR 243

  Fly   241 MWRKTRKP---------SSSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVVGD 296
            :|||.|..         .:..|.|.|.|||||||:.|.|.|||||..||.|..|||||||..|.|
Worm   244 LWRKNRSKMQCRKDIWGRNRCCRGVDLNRNFDFHFRESGTSDDPCSEIYQGPSPFSEPEAKAVRD 308

  Fly   297 LIHS--YVDRGQMYLTLHSYGSLILYPWGWTA-AVPDTEEDLHEVAAAGQSAIQEATGTIYKIGP 358
            .:.|  |..|...|:|||:|..:.::|:|... |.|...:||:||......|::...||.|.:|.
Worm   309 ALLSQRYKGRTDAYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRVYGTKYVVGS 373

  Fly   359 SATTINYAASGASDDYA-FNAGFPISFTMEL---PFGGTGFDPPASDIDSIVKETWVGIAAMARK 419
            .|.|: |.|||.|:|:| ..|.....:.:||   .....||.....::....:|||.|:..:|..
Worm   374 GADTL-YPASGGSEDWAKHEAKVKFVYLLELRPDEKNWDGFILDEKELIPTARETWEGVRVVAEA 437

  Fly   420 VIQK 423
            |:.:
Worm   438 VLDR 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	8/41 (20%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	112/312 (36%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	17/70 (24%)
		M14_CP_A-B_like	128..438	CDD:349433	112/312 (36%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930