DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and Y18H1A.9

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_490776.2	Gene:	Y18H1A.9 / 171666	WormBaseID:	WBGene00021213	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	449	Identity:	137/449 - (30%)
Similarity:	225/449 - (50%)	Gaps:	43/449 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILALSCLSLSAGLQRTNKYEGYKIYEVSSEARSVAFSEALSELVKNASYYEVFSELNAGNPGKIM 71
            |:.|..|.:.:.|....|:..:::...:.:...:..:..|:::  ...:::..||  ||....:|
Worm     3 IIVLIGLVVPSVLAHQKKFTVWRVQPTTQDQVDILHNLYLNDV--KLDFWKSPSE--AGKEVHVM 63

  Fly    72 VHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETNRMLR------HWFPYNGRLGTERYYNH 130
            :...:...|::.::::::|:.::..:|...:..|.|....||      .|.....:....:|::.
Worm    64 ISDEKTQQFMKELDDHSIKHSVMIDDVQKVIVEQKEKRDKLRKQVRLHDWREQKVQFNLAQYHSF 128

  Fly   131 EEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGDARRN---KNVILVDGGFHAREWIS 192
            .::..::..||..:|..|.::.:|.::|||.:..|.|||   :||   |..|.||||.|||||:|
Worm   129 ADVINYLNSLAITYPELVSVQPIGTTHEGRQIPLIKITN---KRNGGTKRGIWVDGGIHAREWVS 190

  Fly   193 PAAATYLINQLV--YNLEDNADLLLD-FDWVILPVVNPDGYEYTQLSED--TRMWRKTRK----- 247
            |:...|.|:|||  |:.:......:| .:|.|:|::|||||||::.|.|  .|:|||.|.
Worm   191 PSTVLYFIHQLVTQYDKDVQIKQFVDQLEWYIVPLLNPDGYEYSRSSNDPEIRLWRKNRSPPKCI 255

  Fly   248 ---------PSSSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSEPEALVVGDLIHSYVD 303
                     |:::.|.|.|.|||||:.:.:.|:|.|||..||.||..|||||...|.|.:..:
Worm   256 QQATGLFQPPTTTCCQGVDLNRNFDWFFGQVGSSTDPCSEIYQGAYAFSEPETAAVRDFVQRH-- 318

  Fly   304 RGQMYLTLHSYGSLILYPWGWTAAVPDTE-EDLHEVAAAGQSAIQEATGTIYKIGPSATTINYAA 367
            |...:||.|||..:::||:|........: .||...|.:...|:.....|.||:|..|.|: |.|
Worm   319 RISTFLTFHSYSQILMYPFGHQVRTYSNDLNDLRSTALSAAQALNSVYNTQYKVGTGADTL-YPA 382

  Fly   368 SGASDDYA-FNAGFPISFTMEL-PFGGT--GFDPPASDIDSIVKETWVGIAAMARKVIQ 422
            ||.|:|:| ..|....||..|| |....  ||....:.|....:|||..:..:|.|.|:
Worm   383 SGGSEDWAKGKAHVKYSFLFELRPEEQVWDGFLLAENQIIPTARETWEAVKVIASKTIE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416	4/33 (12%)
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	116/319 (36%)
Y18H1A.9	NP_490776.2	Propep_M14	29..97	CDD:366995	9/71 (13%)
		M14_CP_A-B_like	125..436	CDD:349433	115/316 (36%)
		ShKT	454..487	CDD:214586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830