Protein Alignment CG18417 and CPA2

DIOPT Version :10

• Sequence 1: NP_648119.1
• Gene: CG18417 / 38829
• FlyBaseID: FBgn0035780
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_001860.2
• Gene: CPA2 / 1358
• HGNCID: 2297
• Length: 419
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 135/393 - (34%)
• Similarity: 202/393 - (51%)
• Gaps: 34/393 - (8%)

  Fly    48 ELVKNASYYEVFSEL------NAGNPGKIMVHPHEQVNFVQL------MEENNVKYDIINRNVGL 100
            |.:||....|....|      :...||:.   .|.:|.||.:      :|...:.|.|:..:|.:
Human    36 EQIKNLLQLEAQEHLQLDFWKSPTTPGET---AHVRVPFVNVQAVKVFLESQGIAYSIMIEDVQV 97

  Fly   101 TLSRQFET---NRMLRHWFPYNGRLGTERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWL 162
            .|.::.|.   ||....    :|......|:..|||:|.:::|..|||..|....:|.|:|.|.:
Human    98 LLDKENEEMLFNRRRER----SGNFNFGAYHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPM 158

  Fly   163 KTITITNGDARRNKNVILVDGGFHAREWISPAAATYLINQLV--YNLEDNADLLLD-FDWVILPV 224
            ..:..:.|.   :|..|.:|.|.|||||::.|.|.:..|::|  |..:.:...:|| .|..:|||
Human   159 NVLKFSTGG---DKPAIWLDAGIHAREWVTQATALWTANKIVSDYGKDPSITSILDALDIFLLPV 220

  Fly   225 VNPDGYEYTQLSEDTRMWRKTR-KPSSSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGAKPFSE 288
            .|||||.::|..  .||||||| |.|.|.|:|.|||||:|..:...|||.:||.:.|.|....||
Human   221 TNPDGYVFSQTK--NRMWRKTRSKVSGSLCVGVDPNRNWDAGFGGPGASSNPCSDSYHGPSANSE 283

  Fly   289 PEALVVGDLIHSYVDRGQMYLTLHSYGSLILYPWGWTAAVPDTEEDLHEVAAAGQSAIQEATGTI 353
            .|...:.|.|.|: .:.:.::|||||..|:::|:|:.....|..::|.|||.....:::...||.
Human   284 VEVKSIVDFIKSH-GKVKAFITLHSYSQLLMFPYGYKCTKLDDFDELSEVAQKAAQSLRSLHGTK 347

  Fly   354 YKIGPSATTINYAASGASDDYAFNAGFPISFTMEL-PFGGTGFDPPASDIDSIVKETWVGIAAMA 417
            ||:||..:.| |.|||.|.|::::.|...||..|| ..|..||..||..|....:|||:|:.|:.
Human   348 YKVGPICSVI-YQASGGSIDWSYDYGIKYSFAFELRDTGRYGFLLPARQILPTAEETWLGLKAIM 411

  Fly   418 RKV 420
            ..|
Human   412 EHV 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<70..105	CDD:460505	9/40 (23%)
		Peptidase_M14	133..412	CDD:459730	109/283 (39%)
CPA2	NP_001860.2	Propep_M14	28..102	CDD:460505	16/68 (24%)
		M14_CPA	118..417	CDD:349442	115/304 (38%)