DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18417 and CPO

DIOPT Version :9

Sequence 1:	NP_648119.1	Gene:	CG18417 / 38829	FlyBaseID:	FBgn0035780	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_775100.1	Gene:	CPO / 130749	HGNCID:	21011	Length:	374	Species:	Homo sapiens

Alignment Length:	337	Identity:	117/337 - (34%)
Similarity:	182/337 - (54%)	Gaps:	25/337 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LTLSRQFETNRMLRHW----FPYNGRLGTERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGR 160
            |...||...::.:..|    :.||      .|:...||.:::.:::.::...|....:|.:||..
Human    25 LAQHRQEIVDKSVSPWSLETYSYN------IYHPMGEIYEWMREISEKYKEVVTQHFLGVTYETH 83

  Fly   161 ---WLKTITITNGDARRNKNVILVDGGFHAREWISPAAATYLINQLVYNLEDNAD---LLLDFDW 219
               :|| |:..:|:.   |.:|.:|.|.||||||:||...:.:.:::.|.:||:.   ||.:.|:
Human    84 PMYYLK-ISQPSGNP---KKIIWMDCGIHAREWIAPAFCQWFVKEILQNHKDNSSIRKLLRNLDF 144

  Fly   220 VILPVVNPDGYEYTQLSEDTRMWRKTRKP-SSSDCIGTDPNRNFDFHWNEEGASDDPCDNIYAGA 283
            .:|||:|.|||.||..::  |:|||:|.| ::..|.|||.||||:..|...|||.:..|..:.|.
Human   145 YVLPVLNIDGYIYTWTTD--RLWRKSRSPHNNGTCFGTDLNRNFNASWCSIGASRNCQDQTFCGT 207

  Fly   284 KPFSEPEALVVGDLIHSYVDRGQMYLTLHSYGSLILYPWGWTAAVPDTEEDLHEVAAAGQSAIQE 348
            .|.||||...|...|.|..|....:||:||||.|||.|:|:|........::.:|.....:|::.
Human   208 GPVSEPETKAVASFIESKKDDILCFLTMHSYGQLILTPYGYTKNKSSNHPEMIQVGQKAANALKA 272

  Fly   349 ATGTIYKIGPSATTINYAASGASDDYAFNAGFPISFTMELPFGGT-GFDPPASDIDSIVKETWVG 412
            ..||.|::|.|| .|.||:||:|.|:|.:.|.|.|:|.||...|| ||..|.:.|....:||...
Human   273 KYGTNYRVGSSA-DILYASSGSSRDWARDIGIPFSYTFELRDSGTYGFVLPEAQIQPTCEETMEA 336

  Fly   413 IAAMARKVIQKY 424
            :.::...|..|:
Human   337 VLSVLDDVYAKH 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18417	NP_648119.1	Propep_M14	<65..99	CDD:280416
CG18417	NP_648119.1	M14_CP_A-B_like	127..420	CDD:199844	109/300 (36%)
CPO	NP_775100.1	M14_CPO	47..344	CDD:133105	111/309 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850