DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8562 and AGBL4

DIOPT Version :9

Sequence 1:	NP_648118.1	Gene:	CG8562 / 38828	FlyBaseID:	FBgn0035779	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_011540610.1	Gene:	AGBL4 / 84871	HGNCID:	25892	Length:	531	Species:	Homo sapiens

Alignment Length:	350	Identity:	77/350 - (22%)
Similarity:	124/350 - (35%)	Gaps:	100/350 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 YTHEEIINYIDDLAQRFPSRVFVKTVGWSYEQRVLKTITITNGDG---KANKKVIFMDGGFHARE 186
            ||:....:|:|.|.:|.....|.:.:|.|.:||.|..:|||:.|.   .|.:||:|:.|..|..|
Human   181 YTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGAEQKVVFITGRVHPGE 245

  Fly   187 -----------------------------WISPAAVLYVIDQLVEQFEENAHLLKDY-DWVILPL 221
                                         |:||.    :||.||.| ...|.:|::| .:.|.|:
Human   246 TPSSFVCQGIPPGHWAALSSSFQNSPGIHWMSPG----IIDFLVSQ-HPIACVLREYLVFKIAPM 305

  Fly   222 VNADG-----YEHTQTG-TLARMWRKTRQPYTYAGQTCYGA---------DPNRNFDFHWNEEGA 271
            :|.||     |..:..| .|.|.|   ..|..:...|.:|.         ||..:.:|:
Human   306 LNPDGVYLGNYRCSLMGFDLNRHW---LDPSPWVHPTLHGVKQLIVQMYNDPKTSLEFY------ 361

  Fly   272 SSNPCADTYAGPTAFSEPETITVRDLMHSLADRGIMYLTL----HSYGNYLLYPWGWTSDLPENW 332
                 .|.:|                 ||....|.||..:    ..:....::|    ..|.:|.
Human   362 -----IDIHA-----------------HSTMMNGFMYGNIFEDEERFQRQAIFP----KLLCQNA 400

  Fly   333 EDLDAVART-GAEAIENATGTVYTYGSSTNVLYIAAGASDDYGY-YAGFNVSITMELPGAGSIGF 395
            ||....:.: ..:|::..||..:..|...:..|........|.| .:|...::.........:|.
Human   401 EDFSYSSTSFNRDAVKAGTGRRFLGGLLDHTSYCYTLEVSFYSYIISGTTAAVPYTEEAYMKLGR 465

  Fly   396 NPPVTRIDEFVTETWIGIRAMAEKV 420
            |...|.:|      :..:..:.|||
Human   466 NVARTFLD------YYRLNPVVEKV 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8562	NP_648118.1	Propep_M14	30..99	CDD:280416
CG8562	NP_648118.1	M14_CP_A-B_like	124..420	CDD:199844	75/348 (22%)
AGBL4	XP_011540610.1	M14_AGBL4_like	190..475	CDD:133118	71/330 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810