DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8562 and AGBL2

DIOPT Version :9

Sequence 1:	NP_648118.1	Gene:	CG8562 / 38828	FlyBaseID:	FBgn0035779	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_079059.2	Gene:	AGBL2 / 79841	HGNCID:	26296	Length:	902	Species:	Homo sapiens

Alignment Length:	347	Identity:	65/347 - (18%)
Similarity:	112/347 - (32%)	Gaps:	129/347 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 YTHEEIINYIDDLAQRFPSRVFVK--TVGWSYEQRVLKTITITN----GDGKANKKVIFMDGGFH 183
            ||:.::..|:..:|.......|.|  |:..|.....:..:||||    ....|.||.:.:....|
Human   398 YTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVVLSARVH 462

  Fly   184 ARE----WISPAAVLYVIDQLVEQFEENAHLLKD-YDWVILPLVNADG-----YEHTQTG-TLAR 237
            ..|    |:....:.:::..     ..:|.||:| :.:.:||::|.||     |..:..| .|.|
Human   463 PGESNGSWVMKGFLDFILSN-----SPDAQLLRDIFVFKVLPMLNPDGVIVGNYRCSLAGRDLNR 522

  Fly   238 MWR---KTRQP---YT------------------YAGQT------CYGADPNR------------ 260
            .::   |...|   ||                  :.|.:      .||.:.|.
Human   523 HYKTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWLHERVFPL 587

  Fly   261 --------NFDFH------------------WNEEGASSNPCADTYAGPTAFSEPET-ITVRDL- 297
                    .|.||                  |.....:|.....|:.|.|..::.:| .|:.||
Human   588 MLCKNAPDKFSFHSCNFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGSTLGNKRDTHFTIEDLK 652

  Fly   298 ---------------------MHSLAD-RGIMYLTLHSYGNYLLYPWGWTSDLPENWEDLDAVAR 340
                                 ...||: :.::...:|...:.|    |...||..:|.|:
Human   653 SLGYHVCDTLLDFCDPDQMKFTQCLAELKELLRQEIHKKFHEL----GQDVDLEGSWSDI----- 708

  Fly   341 TGAEAIENATGTVYTYGSSTNV 362
             ....||::|.     ||.:::
Human   709 -SLSDIESSTS-----GSDSSL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8562	NP_648118.1	Propep_M14	30..99	CDD:280416
CG8562	NP_648118.1	M14_CP_A-B_like	124..420	CDD:199844	65/347 (19%)
AGBL2	NP_079059.2	GVQW	105..>120	CDD:290611
		M14_AGBL2-3_like	407..666	CDD:133117	48/263 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810