DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8562 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_648118.1	Gene:	CG8562 / 38828	FlyBaseID:	FBgn0035779	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	128/451 - (28%)
Similarity:	212/451 - (47%)	Gaps:	48/451 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ATLVAAE---QDYEGYRIYEVIPSTADQADLLHQLSL------QGYDFISETRLLGHPSRVIVSP 69
            |.|:|..   |::..::::.|:|:|..|  ||..:.|      ...||.....::.....::|:|
Worm     8 ALLIAVHSSCQEHGAFKVFRVLPTTNQQ--LLQMIRLFETADTDRADFWHAPSVVNGTVDIMVAP 70

  Fly    70 AQLKHFQQLVEAEKMTLTLVNSNLGASIAEEFAQRQ---------MQRLLAPITGKGRLSTERYY 125
            .....|:|.:|....|..:...:|...:.|:.....         ::||...:....||....||
Worm    71 EHTDQFRQYLEKHGYTFQVAIDDLHKLLIEKEGNLSTHSNDDAFFLKRLHDDVGFHSRLRMGEYY 135

  Fly   126 THEEIINYIDDLAQRFPSRVFVKTVGWSYEQRVLKTITITNGDGKANKKVIFMDGGFHAREWISP 190
            ::..:..:::.:|:..|....:..||.:.|.|.:  :.:..|....:||::.:|.|.|||||.:.
Worm   136 SYSVLSTWLERIAENMPDIAKLIKVGTTIEGRDI--LGLKFGKDTPDKKIVVIDAGIHAREWAAI 198

  Fly   191 AAVLYVIDQLVEQFEENAHLLKDYDWVIL---PLVNADGYEHT---QTGTLARMWRKTRQPYTYA 249
            ....|.|:.:|...||:..:....|.::|   |::|.||||:|   :|...||||||:|.|...|
Worm   199 HTASYFINLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTNPRARMWRKSRSPKACA 263

  Fly   250 -----GQTCYGADPNRNFDFHWNEEGASSNPCADTYAGPTAFSEPETITVRDLMHSLADRGIMYL 309
                 ...|.|.|.||||||.::|.|||..||::.|.||:||||||:......:.||..|...|:
Worm   264 FDGVRNSCCMGVDLNRNFDFRFSEIGASRYPCSEIYHGPSAFSEPESKAYSQFLTSLKGRLEAYI 328

  Fly   310 TLHSYGNYLLYPWG-----WTSDLPENWEDLDAVARTGAEAIENATGTVYTYGSSTNVLYIAAGA 369
            |||||....:|.:.     :..|:    |:...||....:.:....||.|.:|:...::|..:|.
Worm   329 TLHSYSQLWIYSYSHRKFTYAPDI----EETRRVAAKAVQELGRMYGTKYRHGTGPEIIYAFSGG 389

  Fly   370 SDDYGYYA-GFNVSITMEL-PG-AGSIGFNPPVTRIDEFV---TETWIGIRAMAEKVIEMY 424
            |.|:.... ....|.|:|| || .|.|.:|..|...::.:   .|||.|:..:.::|...:
Worm   390 STDWAKETLKIKYSYTIELRPGYEGIIEWNGFVLDKNQLIPTAKETWAGVTVVLDEVTNQW 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8562	NP_648118.1	Propep_M14	30..99	CDD:280416	16/74 (22%)
CG8562	NP_648118.1	M14_CP_A-B_like	124..420	CDD:199844	102/317 (32%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	15/71 (21%)
		M14_CP_A-B_like	134..446	CDD:349433	102/317 (32%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810