DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8562 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_648118.1	Gene:	CG8562 / 38828	FlyBaseID:	FBgn0035779	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	453	Identity:	125/453 - (27%)
Similarity:	211/453 - (46%)	Gaps:	44/453 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFSLGLLVLFLGATLVAAEQDYEGYRIYEVIPSTADQADLLHQLSLQGYDFISETRLLGHPSR- 64
            |.::..||: ||..:.|:...  :.:.:|.::|.:......:.:|.....|........|....
Worm     1 MSYNTSLLI-FLCFSAVSLST--QSFAVYRLLPKSQTDFQAIQRLYKNATDHDLNFWKTGKDKHG 62

  Fly    65 ---VIVSPAQLKHFQQLVEAEKMTLTLVNSNLGASIAEEFAQRQMQRLLAPI---TGKGRLSTER 123
               |:|.....|:|...::...::......::...|.:....:.:..:...:   :.........
Worm    63 FWDVMVDMKNSKYFLDFLQVNDISYIKTIDDVEGLITKHENNKTLSNMFPRLWDDSSSAHYDFHT 127

  Fly   124 YYTHEEIINYIDDLAQRFPSRVFVKTVGWSYEQRVLKTITITNGDGKANKKVIFMDGGFHAREWI 188
            |.:::.:.:::..|..::|..|...::|.:.|.|.:..:.| .||.: .||:.::|||.|||||.
Worm   128 YGSYQRMTDWMKQLVVKYPKMVQYISIGKTTEGRNIDGVEI-GGDSR-TKKIFWIDGGIHAREWA 190

  Fly   189 SPAAVLYVIDQLVEQFEENA--HLLKDYDWVILPLVNADGYEHTQTGT--LARMWRKTRQPYTY- 248
            :|...|:.|.||..:..|..  .||.:..:|::|.:|.||||.|::.|  ..|:|||.|.....
Worm   191 APHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKMQCR 255

  Fly   249 -----AGQTCYGADPNRNFDFHWNEEGASSNPCADTYAGPTAFSEPETITVRDLMHSLADRG--I 306
                 ..:.|.|.|.|||||||:.|.|.|.:||::.|.||:.|||||...|||.:.|...:|  .
Worm   256 KDIWGRNRCCRGVDLNRNFDFHFRESGTSDDPCSEIYQGPSPFSEPEAKAVRDALLSQRYKGRTD 320

  Fly   307 MYLTLHSYGNYLLYPWGWTSD-LPENWEDLDAVARTGAEAIENATGTVYTYGSSTNVLYIAAGAS 370
            .|:|||:|....::|:|...| .|.:.:||..|.:..|:|::...||.|..||..:.||.|:|.|
Worm   321 AYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRVYGTKYVVGSGADTLYPASGGS 385

  Fly   371 DDYG-YYAGFNVSITMELPGAGSIGFNPPVTRIDEFV----------TETWIGIRAMAEKVIE 422
            :|:. :.|.......:||        .|.....|.|:          .|||.|:|.:||.|::
Worm   386 EDWAKHEAKVKFVYLLEL--------RPDEKNWDGFILDEKELIPTARETWEGVRVVAEAVLD 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8562	NP_648118.1	Propep_M14	30..99	CDD:280416	9/72 (13%)
CG8562	NP_648118.1	M14_CP_A-B_like	124..420	CDD:199844	108/319 (34%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	7/66 (11%)
		M14_CP_A-B_like	128..438	CDD:349433	108/319 (34%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930