Protein Alignment CG8563 and CPA4

DIOPT Version :10

• Sequence 1: NP_648116.2
• Gene: CG8563 / 38826
• FlyBaseID: FBgn0035777
• Length: 440
• Species: Drosophila melanogaster
• Sequence 2: NP_057436.2
• Gene: CPA4 / 51200
• HGNCID: 15740
• Length: 421
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 149/442 - (33%)
• Similarity: 226/442 - (51%)
• Gaps: 47/442 - (10%)

  Fly    18 GLGIANNLAGYEGY-----TKYTVQHGDENAFKYMVDLQTNDAELDFWL--LTRNSSVLTVSPRR 75
            |..|.:::.|.|.:     .:..|::|||.: |....:.:|:.:|:||.  .:.|..|..:.|..
Human     8 GALIGSSICGQEKFFGDQVLRINVRNGDEIS-KLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSV 71

  Fly    76 KTQ-FEASLSSLGVSYEMQPLMELMAALQANSSFADDNYDGEYEECQQDECEQAERPRRRTRRQA 139
            ..| |::.|.|.|:.|.: .:.:|.|.|           |.|.:|.|.:|.::         |.:
Human    72 SLQAFKSFLRSQGLEYAV-TIEDLQALL-----------DNEDDEMQHNEGQE---------RSS 115

  Fly   140 RGFFSHYPRYHEVLSF---MSGLAARYPQFCRYESLGRSNEGRHIAALSISLNSRVRPRRVAYIQ 201
            ..|  :|..||.:.:.   |..:||.:|...|...:|.|.|.|.:..|..|....|| |...::.
Human   116 NNF--NYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVR-RPAVWLN 177

  Fly   202 AATHGREWITTQTVLYLAYELLSNLR---AFTRVLQDVEIFLVPLVNPDGYEYTHTTDRFWRKNR 263
            |..|.||||:..|.::.|.:::|:.:   |.|.:|:.::|||:|:.|||||.||.|.:|.|||.|
Human   178 AGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTR 242

  Fly   264 HRYAGHSCSGVDINRNFGNHWNYQGASQNLCSEVYSGTAPNSEPETSAVVRYLEFNRNRVKLSLD 328
            .|..|.||.|.|.|||:...:..:|||.|.|||||.|...|||.|..:||.:::.:.| .|..:|
Human   243 SRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGN-FKGFID 306

  Fly   329 VHSFGKFIFYPYGYAKNTVPPTVGTLRSVALRAANQIGRYRGTRYTTGTSASILYEASGSLDDFA 393
            :||:.:.:.|||||:.... |....|..||..||..:....||.|..|.:.:.:|.||||..|:|
Human   307 LHSYSQLLMYPYGYSVKKA-PDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWA 370

  Fly   394 YGNLGIPLSYTLELPGD---EFHVPAHDIIHVCKETFAGFIEFIRHV--SLY 440
            |.| ||..::|.||...   .|.:||:.||...:||:.|....:.||  :||
Human   371 YDN-GIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8563	NP_648116.2	Peptidase_M14	152..429	CDD:459730	109/285 (38%)
CPA4	NP_057436.2	Propep_M14	27..101	CDD:460505	22/86 (26%)
		M14_CPA	118..419	CDD:349442	116/306 (38%)