DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8563 and ZC434.9

DIOPT Version :9

Sequence 1:	NP_001261515.1	Gene:	CG8563 / 38826	FlyBaseID:	FBgn0035777	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001251356.1	Gene:	ZC434.9 / 172908	WormBaseID:	WBGene00013895	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	120/421 - (28%)
Similarity:	194/421 - (46%)	Gaps:	62/421 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ELDFWLLTRNSSVLTVSPRRKTQFEASLSSLGVSYEM---QPLMELMAALQANSSFADDNYDGEY 117
            :||||                    .:.|.:|...::   :..||.:.::..||:.   :||...
Worm    59 DLDFW--------------------QTPSKVGHRADIMVDEDRMEWLDSVLKNSNI---SYDVII 100

  Fly   118 EECQQDECEQAERPRRRTR------------RQARGFFSHYPRYHEVLSFMSGLAARYPQFCRYE 170
            |:..:...|:...|.|.:.            .:||..|..|..|..:..:|..:..:||...:..
Worm   101 EDVGKLILEKEHGPPRFSNLLFSKRMHNEGGNRARYGFGEYHSYQTICDWMKDIERKYPDKAKVF 165

  Fly   171 SLGRSNEGRHIAALSISLNSRVRPRRVAYIQAATHGREWITTQTVLYLAYELLS--NLRAFTRVL 233
            ::|.::|||.|..:.|........:|:.:|....|.|||....|.|:....|::  |..:..|..
Worm   166 TMGTTSEGRPIQGIKIGSQVWRNDKRIFWIDGGIHAREWAAVHTALWFIDRLIADYNDDSLVRAA 230

  Fly   234 QD-VEIFLVPLVNPDGYEYTHT----TDRFWRKNR--------HRYAGHSCSGVDINRNFGNHWN 285
            .| :..:::|:.|||||||:.:    ..|.|||||        ..:....|.|||:|||:..|:.
Worm   231 VDRLNFYILPVANPDGYEYSRSDVSPMIRLWRKNRAGVVCKKDRWFRDRCCGGVDLNRNYDWHFG 295

  Fly   286 YQGASQNLCSEVYSGTAPNSEPETSAVVRYL---EFNRNRVKLSLDVHSFGKFIFYPYGYAKNTV 347
            ..|:|.:.|||:|.|::..||.||.::..:|   |.| .::...:.:|::.:...:||.:|:.:|
Worm   296 ETGSSTDKCSEIYQGSSAFSESETRSMRDFLTSSELN-GKIDAFITLHTYSQMWIHPYSHARKSV 359

  Fly   348 PPTVGTLRSVALRAANQIGRYRGTRYTTGTSASILYEASGSLDDFAYGNLGIPLSYTLEL-PG-- 409
            |..|..|:.|...|...:....||:|..||.:.|||.::|..||:|.|.|.|...|.||| ||
Worm   360 PADVAELQRVGRAAVAALENTYGTKYKFGTGSDILYPSAGGSDDWAKGTLRIKYVYLLELRPGED 424

  Fly   410 --DEFHVPAHDIIHVCKETFAGFIEFIRHVS 438
              |.|.:..|.:|...|||:.|....||.|:
Worm   425 VWDGFILDQHQLIPTAKETWNGIKVVIRAVT 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8563	NP_001261515.1	M14_CP_A-B_like	146..437	CDD:199844	100/313 (32%)
ZC434.9	NP_001251356.1	Propep_M14	45..111	CDD:366995	14/74 (19%)
		M14_CP_A-B_like	141..454	CDD:349433	100/313 (32%)
		ShK	682..719	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920