DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8563 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_001261515.1	Gene:	CG8563 / 38826	FlyBaseID:	FBgn0035777	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	442	Identity:	131/442 - (29%)
Similarity:	198/442 - (44%)	Gaps:	71/442 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QHGDENAFKYMVDLQTNDAEL---------------DFWLLTR--NSSV-LTVSPRRKTQFEASL 83
            :||   |||....|.|.:.:|               |||....  |.:| :.|:|....||...|
Worm    19 EHG---AFKVFRVLPTTNQQLLQMIRLFETADTDRADFWHAPSVVNGTVDIMVAPEHTDQFRQYL 80

  Fly    84 SSLGVSYE--MQPLMELMAALQANSSFADDNYDGEYEECQQDECEQAERPRRRTRRQARGFFS-- 144
            ...|.:::  :..|.:|:...:.|.| ...|.|..:.:...|:.               ||.|
Worm    81 EKHGYTFQVAIDDLHKLLIEKEGNLS-THSNDDAFFLKRLHDDV---------------GFHSRL 129

  Fly   145 ---HYPRYHEVLSFMSGLAARYPQFCRYESLGRSNEGRHIAALSISLNSRVRPRRVAYIQAATHG 206
               .|..|..:.:::..:|...|...:...:|.:.|||.|  |.:........:::..|.|..|.
Worm   130 RMGEYYSYSVLSTWLERIAENMPDIAKLIKVGTTIEGRDI--LGLKFGKDTPDKKIVVIDAGIHA 192

  Fly   207 REWITTQTVLYLAYELLSNLR----AFTRVLQDVEIFLVPLVNPDGYEYTHTTD-----RFWRKN 262
            |||....|..|. ..|:.|.|    .....|.::.::::|::||||||||.|..     |.|||:
Worm   193 REWAAIHTASYF-INLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTNPRARMWRKS 256

  Fly   263 RHRYA-------GHSCSGVDINRNFGNHWNYQGASQNLCSEVYSGTAPNSEPETSAVVRYLEFNR 320
            |...|       ...|.|||:||||...::..|||:..|||:|.|.:..||||:.|..::|...:
Worm   257 RSPKACAFDGVRNSCCMGVDLNRNFDFRFSEIGASRYPCSEIYHGPSAFSEPESKAYSQFLTSLK 321

  Fly   321 NRVKLSLDVHSFGKFIFYPYGYAKNTVPPTVGTLRSVALRAANQIGRYRGTRYTTGTSASILYEA 385
            .|::..:.:||:.:...|.|.:.|.|..|.:...|.||.:|..::||..||:|..||...|:|..
Worm   322 GRLEAYITLHSYSQLWIYSYSHRKFTYAPDIEETRRVAAKAVQELGRMYGTKYRHGTGPEIIYAF 386

  Fly   386 SGSLDDFAYGNLGIPLSYTLEL-PGDE-------FHVPAHDIIHVCKETFAG 429
            ||...|:|...|.|..|||:|| ||.|       |.:..:.:|...|||:||
Worm   387 SGGSTDWAKETLKIKYSYTIELRPGYEGIIEWNGFVLDKNQLIPTAKETWAG 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8563	NP_001261515.1	M14_CP_A-B_like	146..437	CDD:199844	102/308 (33%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	14/69 (20%)
		M14_CP_A-B_like	134..446	CDD:349433	102/308 (33%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930