DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8563 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_001261515.1	Gene:	CG8563 / 38826	FlyBaseID:	FBgn0035777	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	419	Identity:	118/419 - (28%)
Similarity:	195/419 - (46%)	Gaps:	56/419 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLTRNSSVLTVSPRRKTQFEA-----------SLSSLGVSYEMQPLMELMAALQANSSFAD---- 110
            |.|::.:|..:.|:.:|.|:|           .|:......:.....::|..::.:..|.|
Worm    18 LSTQSFAVYRLLPKSQTDFQAIQRLYKNATDHDLNFWKTGKDKHGFWDVMVDMKNSKYFLDFLQV 82

  Fly   111 ---------DNYDGEYEECQQDECEQAERPRRRTRRQARGF-FSHYPRYHEVLSFMSGLAARYPQ 165
                     |:.:|...:.:.::......||......:..: |..|..|..:..:|..|..:||:
Worm    83 NDISYIKTIDDVEGLITKHENNKTLSNMFPRLWDDSSSAHYDFHTYGSYQRMTDWMKQLVVKYPK 147

  Fly   166 FCRYESLGRSNEGRHIAALSISLNSRVRPRRVAYIQAATHGREWITTQTVLYLAYELLS--NLRA 228
            ..:|.|:|::.|||:|..:.|..:||.  :::.:|....|.|||....|.|:..::|.|  |...
Worm   148 MVQYISIGKTTEGRNIDGVEIGGDSRT--KKIFWIDGGIHAREWAAPHTALFFIHQLTSRANEPG 210

  Fly   229 FTRVLQDVEIFLVPLVNPDGYEYTHTTD----RFWRKNRHRY--------AGHSCSGVDINRNFG 281
            ..::|.::...:||.:||||||:|.::.    |.|||||.:.        ....|.|||:||||.
Worm   211 IKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKMQCRKDIWGRNRCCRGVDLNRNFD 275

  Fly   282 NHWNYQGASQNLCSEVYSGTAPNSEPETSAV------VRYLEFNRNRVKLSLDVHSFGKFIFYPY 340
            .|:...|.|.:.|||:|.|.:|.||||..||      .||    :.|....:.:|::.:...:||
Worm   276 FHFRESGTSDDPCSEIYQGPSPFSEPEAKAVRDALLSQRY----KGRTDAYITLHTYSQIWIHPY 336

  Fly   341 GYAKNTVPPTVGTLRSVALRAANQIGRYRGTRYTTGTSASILYEASGSLDDFAYGNLGIPLSYTL 405
            |:.|:..|..:..|..|..:||..:.|..||:|..|:.|..||.|||..:|:|.....:...|.|
Worm   337 GHKKDAYPGDIKDLYEVGKKAAQALKRVYGTKYVVGSGADTLYPASGGSEDWAKHEAKVKFVYLL 401

  Fly   406 ELPGDE-----FHVPAHDIIHVCKETFAG 429
            ||..||     |.:...::|...:||:.|
Worm   402 ELRPDEKNWDGFILDEKELIPTARETWEG 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8563	NP_001261515.1	M14_CP_A-B_like	146..437	CDD:199844	102/309 (33%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	9/66 (14%)
		M14_CP_A-B_like	128..438	CDD:349433	102/309 (33%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930